|
|
The role of mitochondria in the pathogenesis
Marková, Lenka ; Doležal, Pavel (advisor) ; Verner, Zdeněk (referee)
This thesis is focused on the existing data referring to role of mitochondria in the pathogenesis of several important diseases. It introduces mitochondrial proteins, their role and metabolism, dysfunction of which is behind pathogenetic processes. The thesis also summarizes possible mitochondrial damage, its progress and consequences, which can lead to diseases or aggravate their process. It also pays attention to the role of mitochondria during oncogenesis as well as important neurodegenerative disorders such as Alzheimer's or Parkinson's disease, Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis or autosomal dominant optic atrophy. The thesis mentions the role of disrupted mitochondrial dynamics in type 2 Diabetes. In conclusion the thesis mentions the role of mitochondria and their damage in relation to infection by the parasites Toxoplasma gondii and Trypanosoma cruzi.
|
|
| |
|
|
The use of physiotherapeutic means in some types of tinnitus
Housová, Barbora ; Procházka, Miroslav (advisor) ; Smékal, David (referee)
This thesis is an update of the bachelor work entitled "The application of physiotherapeutic tools for some tinnitus types". The original work was complemented with the latest findings in pathogenesis field and in therapy by physiotherapeutic tool. The fundamental of this diploma thesis is a study examining the quality of patients' lives with tinnitus. The study was based upon a research using a modified questionnaire Tinnitus Handicap Inventory by Newman's et. al. (1999). Powered by TCPDF (www.tcpdf.org)
|
|
|
Tick-borne encephalitis - from pathogenesis to therapy
PALUS, Martin
The proposed thesis contributes to the knowledge about tick-borne encephalitis and its pathogenesis. The thesis describes pathogenesis and immunopathogenesis of tick-borne encephalitis, impact of host's genotype in clinical course determination, immune response of patients with acute tick-borne encephalitis, the mechanism of tick-borne encephalitis virus migration into central nervous system and virus interaction with cells of neurovascular unit as well as potential medical interventions.
|
|
|
Epidemiology and pathogenesis of Escherichia coli
HUBKOVÁ, Petra
Escherichia coli is one of the most important representatives of intestinal microflora. It contributes to the proper course of digestive processes in the gut, creating a beneficial cooperation between microorganism and macroorganism. But some strains may be pathogenic. The scope of my thesis is to get deeply acquainted with the E. coli bacteria, beginning with characteristics, pathogenicity and pathogenesis, laboratory diagnostics and ending with the clinical picture of the disease and therapy. From an epidemiological perspective, pathogenic E. coli appears rather sporadically, but in developing countries can grow up into endemics, especially because of the lack of hygiene. Described are reservoirs, transmission routes and the most famous cases of E. coli occurrence. In the practical part, I focus on the incidence of E. coli in preterm infants, newborns and children up to 3 years old, which are examined with a diarrheal disease diagnosis. During the period from January 2015 to December 2015, 1518 stools from children aged 0 3 years were examined, whereas 25 stools were positive for dyspeptic strains of E. coli, which is the originator of diarrhea. Different non-pathological and pathological flora was proven in 725 stools and non-dyspeptic strain of E. coli was ascertained in 768 stools, which is not the originator of diarrhea. All 1518 stools were examined using classical methods of identification, such as cultivation and biochemical tests (ENTEROtest, a wide range of sugars). To determine the specific serotype (O antigen) of E. coli, serotyping (antigenic analysis of strain) was performed on examined bacterial strain using slide agglutination method. On the basis of proven E. coli serotype, results were statistically analyzed and evaluated in order to determine the strain of E. coli.
|
guest ::
