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Deposition of Inhalants in the Human Respiratory Tract
Kovářová, E. ; Ždímal, Vladimír
Size distributions were determined of particles generated by two types of aerosol inhalers, using three different dosage forms, each of them containing another active substance. It was found that only 6% of inhaled particles deposit in the target region even though 90% of them reach this region. When holding the breath after dose aplication, the deposition efficiency may increase a little. Despite some differences between the individual dosage forms none of them proved to be too beneficial in terms of particle deposition efficiency in the target region. Measurements under various temperatures and relative humidities showed that all studied inhalants are hydrophobic; the measured size distributions essentially did not change even at high relative humidities simulating conditions in the real respiratory tract.
Analýza časových řad distribuce velikosti částic
Wagner, Zdeněk ; Schwarz, Jaroslav ; Ždímal, Vladimír ; Eleftheriadis, K. ; Lazaridis, M. ; Smolík, Jiří
The paper presents a method for filtration of particle count measurement in the time domain. The goal of this method is to remove extremal values caused by short-time instrument malfunction but preserve values representing fast events. The method offers interpolation of particle size distribution so that in can correlated with other variables measured at different time intervals.
Robustní odhad rozdělení velikostí částic atmosférických aerosolů pomocí gnostické teorie
Wagner, Zdeněk ; Ždímal, Vladimír ; Smolík, Jiří
A new approach using gnostic theory of uncertain data is applied to analysis of particle size distribution in atmospheric aerosols. The properties of the gnostic kernel, derived from theory, is demonstrated. Enhancement of gnostic theory, which allows robust kernel estimation of the distribution function as well as the bounds of the data support, is explained.

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