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Computed tomography of the intestinal tract, usage, advantages and disadvantages of this metod
SMOLÁKOVÁ, Eva
In presented essay author tries to offer comprehensive overview of possibilities of computer tomography (CT) in examination of the intestinal tract at her radiologic department. Introduction of Multidetector CT represents outstanding advance in spatial resolution in z - axis and accelerated data acquisition wihout increase of radiation dose. All these advantages of Multidetector CT project strongly onto examination of the intestines. At author´s department CT enterography and CT colonography replaced to the background classic methods as irrigoscopy and enteroclysis. The feasibility of assessment of the intestinal tract and other abdominal organs at the same time is the most significant contribution of this method. At our department we note progressive decrease of number of enteroclysis examinations since the year 2003. Limitations of this method are radiation exposure, intravenous application of iodine contrast medium and impossibility to obtain specimens for histologic examination. We expect, that future technologies will reduce some of these disadvantages.
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Analýza genové exprese kolorektálního karcinomu detekované cDNA mikročipy pomocí kombinace různých vyhodnocovacích přístupů
Jansová, E. ; Krontorád, P. ; Svoboda, Z. ; Koutná, I. ; Pavlík, T. ; Kozubek, Michal ; Jarošová, M. ; Žaloudík, J. ; Kozubek, Stanislav
We have compared colorectal carcinoma tissues with parallel samples of epithelial tissue and identified, by means of Human 1.7K cDNA microarrays, a set of genes with significantly altered expression in 12 patients. We used a combination of several approaches of microarray data analysis to be sure that the results were reliable. Although we have found differences between the results obtained by various image analysis software packages and using different statistical tools, we have identified the group of 22 genes with significantly altered expression in colorectal carcinoma tissue as compared with epithelial tissue using all evaluation approaches. Hierarchical clustering showed the possibility of dividing the patients into two groups according to the presence of metastases in regional lymph nodes. We have proposed 6 genes as potential markers for the detection of the presence of regional metastases in patients.
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