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Sensitivity of \kur{Borrelia burgdorferi} sensu lato complex to complement of different wild, domestic animals and humans: host-patogen interaction.
TICHÁ, Lucie
Sensitivity of Borrelia burgdorferi sensu lato to serum complement from various animals and humans was analyzed. Complement-mediated Borrelia killing was observed in different combination of host serum and Borrelia genospecies. The obtained results revealed species-specific patterns of viability or mortality of spirochetes that is associated with host reservoir competence for Borrelia genospecies. The results confirmed the fact that parasite-host relationship determines the competent reservoir of Borrelia genospecies in nature. The complement of the host may have a key role in the global ecology of Lyme disease.

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