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The Results of Radiotherapy in Tumors of the Vocal Cords
HRDLIČKA, Vojtěch
Malignant tumors of vocal cords are the less common, but not rare carcinomas. My thesis contains information on results of radiotherapy in tumors of the vocal cords in terms of recurrence and five-year survival rates for early stage disease. It's also included statistics containing information about rescue total laryngectomy, radiation techniques and within hypothesis are compared results of radiotherapy of IMRT and CRT techniques. Also compared are doses delivered to the target volume. The aim is then compare results with literature and assess whether the indicated dosage affects the efficacy of curative radiotherapy. This work is supported by quantitative statistical survey in the range of 106 patients. Data was obtained for South Bohemian Region, in the archive of the Oncology Department in the Hospital České Budějovice, a.s. in the range of 2000 2009. In the total group of 91 curative irradiated patients was found 57,54 % preponderance representation of T1 tumors and 21,69 % of T2 tumors. Five-year survival of patients with stage T1 corresponds to 90,16 % and 69,57 % of T2 stage. Rescue laryngectomy was performed a total of 12 with an average extension of life of patients by 5 years. A dose used for IMRT and conformal technique was found to be lower than literature recommends.
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Radiotherapy of prostate tumours through the IMRT technique and its toxicity
VRÁNOVÁ, Jana
Abstract Radiotherapy of prostate tumours through the IMRT technique and its toxicity In today´s modern world, prostate carcinoma is one of the most frequent malignant diseases suffered by men. Most ill persons who suffer from this disease are men between 50 and 70 years, and their number is increasing more and more. My work deals with occurrence of late complications after radiation of patients with prostate carcinoma through the IMRT technique in Nemocnice České Budějovice, a.s.. I assessed the number of late complications in the area of gastrointestinal and genito-urinary tract, degree of damage, and period of latency in dependence on a technique and amount of radiation. I observed whether the number of late complications is comparable with data in professional literature, or whether it considerably differs from these results. Method for preparation of an expert study being quantitative research. I obtained data from the files of the Department of Oncology of Nemocnice České Budějovice, a.s., in 2007-2010. From the group of 243 patients, there were 211 patients appropriate for statistical processing of my research who were exposed to radiation through the IMRT technique due to prostate carcinoma diagnosed in 2007 - 2010. There were complications with 114 of them (54.03%). In the area of gastrointestinal tract, the 1st degree of late toxicity was with 47 patients (88.68%), 2nd degree with 4 patients (7.56%) and 3rd degree with 2 patients (3.77%). Median value of the period of latency is 13.86 months. Undesirable effects were shown in 3 months at the earliest, in 39 months at the latest. In the area of genito-urinary tract, the 1st degree of toxicity was with 39 patients (82.98%), 2nd degree with 8 patients (17.02%), and 3rd degree did not occur at all. Median value of the period of latency is 10.3 months. First, there occurred symptoms of late toxicity in 2 months, in 30 months at the latest. Upon comparison of all the results which I found out during my research done, I arrived at the conclusion that in Nemocnice České Budějovice, a.s., the occurrence of late toxicity of the second and third degree is slightly smaller in the area of gastrointestinal tract, while in the area of genito-urinary tract late complications of the second and third degree occur more often.
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