National Repository of Grey Literature 16 records found  previous11 - 16  jump to record: Search took 0.00 seconds. 
\kur{In vitro} metody rekrutace a migrace leukocytů a jejich použití při studiu vlivu proteinů z klíštěcích slin na imunitní systém hostitele
KAŠPAR, Tomáš
In this work, I managed to optimize in vitro method of static migration of neutrophils. This method included isolation of the neutrophils, specifically optimizing the concentrations of the individual layers of the Percoll gradient and identifying the optimal concentration of fMLP to stimulate neutrophil migration. This optimized method was used to test the effect of five tick protease inhibitors, from Ixodes ricinus saliva on neutrophil migration.
Electron microscopic analysis of processes in progress during cancer immunotherapy based on use of TLR agonists and the ligands of phagocytic receptors
NEDBALOVÁ, Pavla
The ligands of phagocytic receptors anchored in the membrane of tumour cells in combination with TLR agonists cause strong neutrophils infiltration within the tumour. These neutrophils are able to direct tumour cell lysis. Ultrastructure analysis of tumour with aim to determine mechanisms of tumour cell damage by neutrophils was performed with transmission electron microscope.
The searching of TLR agonists working in synergy with ligands of phagocytic receptors in the cancer therapy
JAČKOVÁ, Adéla
The main goal of this thesis was to optimize the current therapeutic approach using TLR agonists and anchored agonists of phagocytic receptor to treating cancer. The study is focused on searching a suitable agonist of TLR as the replacement of LPS.
Study of clinically applicable cancer immunotherapy and their mechanisms
GLASEROVÁ, Simona
The aim of this thesis was study of replacement of LPS in innate immunity based cancer immunotherapy. Application of poly (I:C) with mixture of mannan-SMCC + R-848.HCl leads to synergy, higher reduction of tumor growth and significant prolongation of survival. The significance and mechanism of action of neutrophils have also been studied within this therapy.

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