National Repository of Grey Literature 14 records found  previous11 - 14  jump to record: Search took 0.01 seconds. 
Parasitism and diversity in MHC genes in small rodents
VEJSADA, Lukáš
This thesis provides a review of issues connected to the study of MHC in small rodents. Also an assesment of the diversity of MHC allels in the mouse Apodemus is evaluated.
Characterization of two members from the multigenic family of one-domain Kunitz-inhibitors from the tick \kur{Ixodes ricinus}
SINGEROVÁ, Barbora
Two new genes encoding proteins Monolaris 1 and Monolaris 2 were isolated from tick Ixodes ricinus. Both cDNA fragments code for 94 aminoacid residues long protein with molecular mass 8,1kDa (Monolaris 1) and 8,3kDa (Monolaris 2). The function of Monolaris 1 was tested by using RNA interference in adult females of Ixodes ricinus that were subsequently fed on guinea-pigs. Body mass, egg mass and mortality were measured to evaluate the effect of gene silencing. Recombinant protein Monolaris 1 was prepared in bacterial expression system and antibodies against this protein were raised by immunization of a rabbit. Antibodies reacted with approximately 190kDa big protein in salivary gland, ovary and gut whereas monomer of Monolaris 1 was not detected in tick saliva, salivary glands and other tissues.
Ethical problems in organ´s extraction towards transplantation
ESCOBAR CASTILLO, Javier Jesus
The present bachelor thesis is concerned with organ transplantation with the view to the associated ethic problems. The theoretical part consists of the introduction into the problems of this fast developing medical field, and refers to the legislative treatment of organ transplantation in the Czech Republic. The outlined transplantation process as a medical branch is the basis from which a number of social issues arise {--} issues related to morals, the law, and human relations and similar. The conclusion of the theoretical part formulates the aforesaid issues as the principal ethic problems: the subject of death, a consent or refusal with the post-mortem organ donation, organ trade and the selection of transplant candidates in the register. Moreover, the theoretical part compares different approaches to organ transplantations adopted in other countries, together with recommendations of the European Union. The thesis emphasizes the fact that to comprehend these sensitive ethic issues the public need to be informed, so the social consensus can be reached. The aim of the thesis is to determine the predispositions of the students of the Faculty of Health and Social Studies to donate organs, or their willingness to accept organs in the role of ill recipients. The adopted working hypotheses lay in such assumptions that on the one hand, students{\crq} approach to organ donation tends to be negative should they become donors; and, on the other hand, their approach is positive should they become recipients themselves. Another hypothesis assumed a certain lack of knowledge of the organ transplantation problems on the students{\crq} part, the fact of which renders the distribution of important information among the public virtually impossible. The research was conducted by means of questionnaires. The research results acquired from students were compared with the latest nationwide survey carried out by Factum Invenio, the marketing service company which is professionally concerned with such surveys. Needless to say, the abovementioned hypotheses were not confirmed by our research. On the contrary, the research ascertained high altruism and revealed a relatively good grasp of the organ transplant problems in most of the respondents. These facts are even more noticeable when compared with the nationwide research. Our research proved that students neither have ethic problems with the organ donation itself, nor with the ethically controversial and legislatively established strategy of obtaining organs: the strategy that saves human lives. Apparently, our respondents{\crq} moral standards of social justice are higher than those of the public as a whole. If our respondents spread their awareness of the problems among the public in concert with their viewpoints, they could contribute to the hope for a meaningful life with a transplanted organ of a diseased person on the waiting list.

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