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National Repository of Grey Literature 12 records found  previous11 - 12  jump to record: Search took 0.01 seconds. 
The adenylyl cyclase signaling system in normal and failing myocardium
 Karlovská, Ivana ; Novotný, Jiří (advisor) ; Svatoňová, Anna (referee)
This bachelor thesis describes a signal pathway of adenylyl cyclase, which plays a key role in the modulation of heart rate and force of contraction. This pathway begins with membrane-bound β- adrenergic receptors that activate the enzyme adenylyl cyclase. Adenylyl cyclase produces second messengers by reverting ATP to cAMP. Several changes occur in this pathway in failing heart. The most striking changes occur in β-adrenergic receptors, but there are some changes on the level of adenylyl cyclase and G proteins as well. Most of these changes are related to chronic high levels of catecholamines, especially norepinephrine. Some medications try to reverse these adverse effects of norepinephrine. β-blockers are traditional drugs for treating heart failure. However, adenylyl cyclase may be also considered as potential target for pharmacotherapeutic interventions in the future. Powered by TCPDF (www.tcpdf.org)
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Effect of chronic morphine treatment of rats on myocardial signaling systems regulated by trimeric G-proteins
 Škrabalová, Jitka ; Novotný, Jiří (advisor) ; Rudajev, Vladimír (referee)
It has recently been discovered that the effect of morphine can significantly reduce the tissue damage that occurs during myocardial ischemia. The molecular mechanisms by which morphine acts on the heart are still little understood. The aim of this thesis was to monitor the effect of chronic 27-day and 10-day administration of low (1 mg/kg/day) and high (10 mg/kg/ day) doses of morphine on the expression of selected G-protein-coupled receptors (GPCR) and on the expression and activity of adenylyl cyclase (AC). Chronic (27 days) morphine treatment reduced the expression of к-opioids receptors, but 10-day morphine exposure did not influence the expression of these receptors. Assessment of β1- and β2-AR by immunoblot technique did not show any significant change in the expression, but the more accurate determination of β-AR expression using the saturation binding studies revealed that 27-day treatment with high doses of morphine appreciable increased the total number of these receptors. Administration of high doses of morphine led to marked up-regulation of adenylyl cyclase (AC) isoforms V/VI, and the amount of AC decreased proportionally with the time of discontinuation of morphine administration. Low doses of morphine up- regulated AC only during 27-day administration. Chronic morphine exposure did...
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National Repository of Grey Literature : 12 records found   previous11 - 12  jump to record:
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