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An Effect of Facilitation Physiotherapy on Immune Parameters of Patients with Multiple Sclerosis
Řasová, K. ; Brandejský, P. ; Kučera, P. ; Martinková, Patrícia
Introduction: New neurophysiologic knowledge brings new possibilities of physiotherapy – a potential influence of the immune system in sense of immunomodulation. In this study, the impact of facilitation physiotherapy (FP) on the humoral and cellular immunity in patients with multiple sclerosis (MS) was monitored. Methods: Plasma immunoglobulins and membrane markers were measured in 20 stable MS patients twice during two months. During this time, 12 patients underwent 2 months FP and 8 did not change their habits. Plasma immunoglobulins were measured by laser nephelometry and membrane markers were stained by monoclonal antibody conjugated with fluorochromes and analyzed by flow cytometry. Wilcoxon signed-rank (paired) test and Wilcoxon rank-sum (two-sample) test was used for analyses. Results: We found significant changes in patients after FP in number of immunological parameters (IgG, IgG1, IgA, CD3+CD8+, CD3+, NK cells, lymphocytes, neutrophiles. while in patients who did not change their habits, there was a significant increase only in IgA. However, the amount of changes after two months follow-up was significantly different in the two groups only in IgA (p = 0.008). Conclusion: FP in MS influences the immunologic profile of patients with MS.
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