|
|
Ambient Organic Aerosol Origin at Rural Background Site in the Czech Republic.
Lhotka, Radek
Atmospheric aerosol (AA) are ubiquitous particles in the atmosphere that influence Earth’s climatic system, environmental interactions,\nand human health. AA is emitted directly from primary sources or formed in the atmosphere via the oxidation of gas-phase precursors\nwith subsequent partitioning resulting in low-volatility products into the particle phase. Among AA, great interest is dedicated to organic\naerosol (OA) since it can represent from 20 to 90% of the total submicron mass.
Plný tet:  PDF
|
|
| |
|
| |
|
| |
|
| |
|
|
Supercritical Impregnation of Natural Extracts in Polymer.
Komárková, Anežka
The vision of this work is to prepare polymeric support loaded with natural extracts and their bioactive compounds in order to create\nwound dressing with anti-inflammatory and anti-bacterial properties. The use of such a dressing may contribute to the wound’s healing\nmechanism by creating a proper physiologic environment, being a barrier for microorganisms and releasing bioactive compounds to the\nwound site.
Plný tet: PDF
|
|
|
Synthesis and Cytotoxicity of Fluorinated Amino Saccharides.
Hamala, Vojtěch
This work presents the synthesis of acetyl, propionyl, and butyrylesters of monofluorinated, difluorinated, and trifluorinated analogues\nof N-acetyl-d-glucosamine and N-acetyl-d-galactosamine, and theircytotoxicity expressed as IC50 values against the MDA-MB-231 cancer\ncell line (triple-negative breast cancer) along with their IC50 valuesagainst the HEK-293 non-cancerous cell line.
Plný tet: PDF
|
|
|
Deoxyfluorinated N-acetyllactosamines as Tailored Carbohydrate-based Probes for Human Galectins.
Kurfiřt, Martin
this work, I prepared a complete series of mono‑deoxyfluorinated N-acetyllactosamine analogues 1-6. The synthesis of each analogue\nrequired approximately 15 synthetic steps, including deoxyfluorination of monosaccharide precursors, chemical glycosylation and\ndeprotection. Their binding affinities to the two most explored human galectin-1 and -3 were determined by ELISA and 19F NMR T2-filter\ntechniques, which enabled the identification of hydroxyl groups, crucial in the non-covalent recognition by galectins. This binding study\nalso permitted to compare both tested galectins in terms of their substrate specificity, revealing subtle differences, which could be utilized\nin the development of selective galectin inhibitors. Furthermore, the series is also a perfect tool to study the molecular origin of recognition\nevents via epitope-mapping 19F NMR techniques.
Plný tet: PDF
|
|
|
Modular Synthesis of Dendritic Amphiphiles.
Edr, Antonín
The synthesis of such structures starts by an attachment of alkyl chain/s R and dendritic wedge/s to the starting molecules. These dendritic wedges are ended by three allyl groups so that various polar groups can be conjugated to the periphery of the wedge by so called thiol-ene click reaction. In addition to the resulting symmetrical structures, a synthesis of their unsymmetrical analogues bearing fluorescent tag on one of its arms (Figure 1) will be presented.
Plný tet: PDF
|
|
|
Solvent Assisted 2D Mesoporous g-C3N4 Modification for Catalytic Application.
Dolai, Susmita
Here we show a facile and scalable new approach for the synthesis of ordered CN materials with an excellent photoactivity, which consists\nof supramolecular interfacial preorganization of monomers at the interface of two non-miscible solvents. Molecular dynamic simulations\nsupported by experimental results reveal that appropriate mono-mers and solvents choice lead to the formation of a supramolecular assembly solely at the interface of the solvents. As a proof of concept, we show the chemical and physical properties of the g-C3N4 materials after thermal condensation in various temperature. The advantages of the new method are demonstrated here through the tuneable morphologies and surface area, the formation of new electronic junctions and high activity as a photocatalyst for hydrogen evolution and pollutants degradation of the g-C3N4 materials.
Plný tet: PDF
|
guest ::
