National Repository of Grey Literature 65 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Adhesive properties of thin layers based on plasticized polyesters
Soukupová, Jana ; Šnejdrová, Eva (advisor) ; Šklubalová, Zdeňka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Name: Jana Soukupova Title of diploma thesis: Adhesive properties of thin layers based on plasticized polyesters Supervisor: PharmDr. Eva Snejdrova, Ph.D. This diploma thesis deals with rheological, adhesive and dissolution properties of thin layers based on the branched polyester of D,L- lactic acid and glycolic acid, plasticized with methyl- salicylate, and loaded with salicylic acid. The theoretical section describes bioadhesion, its mechanism and theories, in vitro adhesive tests focused mainly on the method of rheological synergism, tensile and "wash off" tests. In the experimental section, the flow properties of plasticized polyesters, hydrated mucin from porcin stomach, and their mixtures were studied using absolute rotational rheometer. The analysis of the viscosity curves revealed that plasticized polyesters are Newtonian systems, mucin and its mixtures with polymer have pseudoplastic behaviour. Adhesive properties of the thin layers were established by equation of rheological synergism based on viscosity of polymer, mucin and their mixtures measured at shear rate of 10 s-1 . The adhesive properties of thin layers were also determined using tensile test on rheometer, and evaluated as the...
Analysis of hereditary genetic variants predisposing to the development of familial forms of ovarian cancer.
Lhotová, Klára ; Soukupová, Jana (advisor) ; Mohelníková Duchoňová, Beatrice (referee) ; Weinberger, Vít (referee)
Ovarian cancer (OC) is the deadliest gynecologic malignancy with a substantial proportion of hereditary cases and a frequent association with breast cancer (BC). Genetic testing facilitates preventive management for carriers of mutations in OC-susceptibility genes. However, the prevalence of germline mutations varies among populations and many rarely mutated OC predisposition genes remain to be identified. We analyzed 219 genes in 1333 Czech OC patients and 2278 population-matched controls (PMC) using next-generation sequencing. Altogether, 427/1333 (32%) patients and 58 /2278 (2,5%) PMC carried pathogenic mutations in 18 known/anticipated OC predisposition genes. Mutations in BRCA1, BRCA2, RAD51C, RAD51D, BARD1 and mismatch repair genes conferred a high OC risk (with OR>5). Mutations in BRIP1 and NBN were associated with moderate risk (both OR ≥2 - <5). BRCA1/2 mutations dominated in almost all clinicopathological subgroups including sporadic borderline tumors of ovary (BTO). Analysis of remaining 201 genes revealed somatic mosaics in PPM1D and germline mutations in SHPRH and NAT1 associating with a high/moderate OC risk significantly; however, further studies are warranted to delineate their contribution to OC development in other populations. Results of this study demonstrate the high proportion...
Artificial intelligence as a challenge to private law
Soukupová, Jana ; Kučera, Zdeněk (advisor) ; Frinta, Ondřej (referee)
Artificial intelligence as a challenge to private law Abstract The subject of this master thesis is private law and artificial intelligence. The main goal of this thesis is the analysis of private law aspects of artificial intelligence and the evaluation of current laws regarding this technology. Therefore, the thesis mainly deals with the legal status of artificial intelligence within the current law and the possible granting of the status of an electronic person. It also deals with the issue of appropriate regulation of artificial intelligence in the future. The first part of the thesis is focused primarily on the concept of artificial intelligence, its importance for society and law and its risks. The primary goal of this chapter is to acquaint the reader with the functioning of artificial intelligence as a technology, while considering its differences from other technologies, especially its autonomy. The second part of the thesis is then focused on a critical analysis of artificial intelligence in terms of current law, according to which artificial intelligence can be considered a thing in the legal sense, a product or an author's work. Part of this chapter is also focused on the issue of protection of works or inventions created by artificial intelligence and on the considerations of artificial...
Adhesive properties of thin layers based on plasticized polyesters
Soukupová, Jana ; Šnejdrová, Eva (advisor) ; Šklubalová, Zdeňka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Name: Jana Soukupova Title of diploma thesis: Adhesive properties of thin layers based on plasticized polyesters Supervisor: PharmDr. Eva Snejdrova, Ph.D. This diploma thesis deals with rheological, adhesive and dissolution properties of thin layers based on the branched polyester of D,L- lactic acid and glycolic acid, plasticized with methyl- salicylate, and loaded with salicylic acid. The theoretical section describes bioadhesion, its mechanism and theories, in vitro adhesive tests focused mainly on the method of rheological synergism, tensile and "wash off" tests. In the experimental section, the flow properties of plasticized polyesters, hydrated mucin from porcin stomach, and their mixtures were studied using absolute rotational rheometer. The analysis of the viscosity curves revealed that plasticized polyesters are Newtonian systems, mucin and its mixtures with polymer have pseudoplastic behaviour. Adhesive properties of the thin layers were established by equation of rheological synergism based on viscosity of polymer, mucin and their mixtures measured at shear rate of 10 s-1 . The adhesive properties of thin layers were also determined using tensile test on rheometer, and evaluated as the...
Comparison of the Macroeconomic Development of the Slovak Republic, the Czech Republic and the Netherlands
Stankovičová, Diana ; Krameš, Jaroslav (advisor) ; Soukupová, Jana (referee)
Aim of this bachelor's thesis is to compare economic development of the Slovak Republic, the Czech Republic and the Netherlands. The goal is to choose and evaluate the macroeconomic development of the mentioned countries in the time period from the year 2008 until the year 2016. Indicators as export, import, net export, exchange rate, inflation rate, unemployment rate and gross domestic product were used. In the theoretical part, the chosen indicators of economic performance are defined and explained. The practical part is focused on the analysis of these indicators of the chosen countries and on the following comparison (development between years, development between countries). Outcome from the identified analyses are evaluations and recommendations for the chosen countries, how it is possible to improve the situation in the countries to achieve higher economic productivity and stability.
Alternative theories of the firm
Myakotskiy, Dmitriy ; Soukupová, Jana (advisor) ; Džbánková, Zuzana (referee)
This paper covers the issue of alternative theories of the firm. The theoretical part is separated into two chapters and their goal is to acquaint readers with this topic of microeconomics. On the base of described models will be explained ambiguous approach to theme. After this, follows the explanation of Corporate Social Responsibility (CSR). This chapter contains conceptual bases and model of CSR, which reference to the main theme of the paper - alternative theories of the firm and help to answer the question: Can Corporate Social Responsibility be concerned as a theory of firm? The next chapter describes the concept of CSR at the examples of CSR projects in Marks & Spencer company.
Characteristics of demand for healthy nutrition products
Nováková, Šárka ; Soukupová, Jana (advisor) ; Džbánková, Zuzana (referee)
This bachelor thesis deals with the issue of the demand for healthy nutrition products on the Czech market. Its aim is to find out whether there is a demand for healthy nutrition products in the Czech Republic. The theoretical part contains an explanation of basic concepts related to the demand and healthy nutrition. The practical part focuses on research itself, which analyzes the demand for these products. The research is done through a questionnaire survey.
China´s business environment
Hadroušek, Daniel ; Hořejší, Bronislava (advisor) ; Soukupová, Jana (referee)
This bachelor thesis deals with the business environment in the Chinese market. The aim of this work is to analyze the political, legal, economical and socio-cultural environment in China. The theoretical part deals with the characteristics of the four environments in general and examines the approaches of different authors to international business. The practical part analyzes the political, legal, economical and socio-cultural environment in China. The analysis of environment for business in the Chinese market can help Czech companies in entering this market. In the conclusion is a summary of all the environments and brief outline of threats and opportunities in the Chinese market for foreign investors.
The impact of the automotive industry on the selected macroeconomic indicators of the economy of the Slovak Republic
Sabol, Samuel ; Nečadová, Marta (advisor) ; Soukupová, Jana (referee)
The aim of this bachelor thesis is to investigate and analyze the position and influence of the automotive industry on the selected macroeconomic indicators of economy of the Slovak Republic. This work consists of two parts, theoretical and practical. The theoretical part focuses on the position and significance of the automotive industry for the Slovak economy along with the characterization of selected macroeconomic indicators. In the practical part, I mean specific macroeconomic indicators (GDP, unemployment, foreign trade), which analyze the data obtained from the Slovak Statistical Office and EUROSTAT. Consequently, I examine the importance of automotive production in Slovakia through changes in the macroeconomic indicators in a given time period.
Corruption rate and economic performance
Hořejší, Zuzana ; Soukupová, Jana (advisor) ; Džbánková, Zuzana (referee)
This Bachelor´s thesis is focused on a level of corruption and economic influence in selected countries of EU. Theoretical part is focused on a description of the term of corruption, types of corruption, forms of measuring corruption and last but not least causes and consequences of corruption. The basis of the practical part is a regression and correlation analysis which I apply to observed indicators in selected countries of EU. These observed indicators are CPI, GDP in PPP, and Legatum Prosperity Index. The aim of my thesis is to find out if there is a relation among these indicators and then how strong is a dependency among them.

National Repository of Grey Literature : 65 records found   1 - 10nextend  jump to record:
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