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Segmentation and morphological analysis of mouse embryo choroid plexus
Parobková, Viktória ; Jakubíček, Roman (oponent) ; Chmelík, Jiří (vedoucí práce)
The Choroid Plexus is a regulated gate between blood and cerebrospinal fluid and takes place in several functions connected with the neural system. However, many functions are still unknown caused by the fragility, location and shape of the plexus. Thus the noninvasive techniques are used to access this crucial brain component located within the ventricles. Moreover, there is a link between its shape and brain pathologies. This project aimed to extract the ChP of the 4th ventricle by implementing segmentation methods followed by morphological analysis to discover patterns between the shape and disease.
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Bioinformatic analysis of single nucleotide polymorphisms in the 1000 Genomes Project database
Parobková, Viktória ; Roy, Sudeep (oponent) ; Provazník, Ivo (vedoucí práce)
The whole-Genome sequencing and its variations discovery were challenging for many years. The knowledge of all genetic variations is remarkably beneficial in disease research. The bachelor thesis is dedicated to human genetic variations and its two main research projects, the HapMap Project and the 1000 Genomes Project which notably helped the disease analyses. The first part describes both Projects and the following part explains the structure of their databases and presents software which enables to browse and download data from these projects. At last, statistical, population and bioinformatic analyses are performed on structural variant dataset assembled by the 1000 Genomes Project.
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Segmentation and morphological analysis of mouse embryo choroid plexus
Parobková, Viktória ; Jakubíček, Roman (oponent) ; Chmelík, Jiří (vedoucí práce)
The Choroid Plexus is a regulated gate between blood and cerebrospinal fluid and takes place in several functions connected with the neural system. However, many functions are still unknown caused by the fragility, location and shape of the plexus. Thus the noninvasive techniques are used to access this crucial brain component located within the ventricles. Moreover, there is a link between its shape and brain pathologies. This project aimed to extract the ChP of the 4th ventricle by implementing segmentation methods followed by morphological analysis to discover patterns between the shape and disease.
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Bioinformatic analysis of single nucleotide polymorphisms in the 1000 Genomes Project database
Parobková, Viktória ; Roy, Sudeep (oponent) ; Provazník, Ivo (vedoucí práce)
The whole-Genome sequencing and its variations discovery were challenging for many years. The knowledge of all genetic variations is remarkably beneficial in disease research. The bachelor thesis is dedicated to human genetic variations and its two main research projects, the HapMap Project and the 1000 Genomes Project which notably helped the disease analyses. The first part describes both Projects and the following part explains the structure of their databases and presents software which enables to browse and download data from these projects. At last, statistical, population and bioinformatic analyses are performed on structural variant dataset assembled by the 1000 Genomes Project.
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