National Repository of Grey Literature 11 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Prevention and therapy of recurrent Clostridioides difficile infection
Polívková, Sylvia ; Beneš, Jiří (advisor) ; Krbková, Lenka (referee) ; Rožnovský, Luděk (referee)
Introduction: Clostridioides difficile infection (CDI) is the most common nosocomial gastrointestinal infection, it is associated with antibiotic use and due to the spread of epidemic strains of C. difficile, there are differences in the course and severity of the disease. This study aimed to describe the characteristics of patients with CDI, to perform molecular analysis of isolates , and then to correlate CDI course and treatment outcomes with the causative ribotypes. Furthermore, the efficacy of antibiotic regimens in the treatment of CDI was evaluated with the severity and number of CDI episodes. Methods: The observational cohort study was conducted in 2013-2016 at the Department of Infectious Diseases of the Bulovka University Hospital in Prague. Patients with laboratory-confirmed CDI were included in the study. C. difficile isolates were characterized by ribotyping, multiple variable tandem repeat analysis (MLVA) and examination of antibiotic resistance determinants (mutations in gyrA, gyrB, rpoB genes or the presence of ermB). Univariate logistic regression was used to evaluate the efficacy of antibiotic regimens (metronidazole, vancomycin, combination of vancomycin and metronidazole, fidaxomicin). Subgroup analyses were performed based on the number and severity of CDI episodes. Results: A...
Use of statistical methods to evaluate activities in the language school Lingua Plus, ltd.
Krbková, Lenka ; MBA, Hana Neznalová, (referee) ; Kropáč, Jiří (advisor)
In my bachelor thesis I will analyse and evaluate work efficiency in the language school LinguaPlus, s.r.o. with the help of statistical methods. I will elaborate a model which would inform the company about its future activities development either under the same conditions, or after changing some characteristics. This model will be helpful for the company, will explain ineffective steps in the past, and precautions for the future.
Proposal of Methodology of Monitoring of Employees
Klimeš, Roman ; Krbková, Lenka (referee) ; Pokorný, Jiří (advisor)
My thesis will serve as a monitoring tool for the management of an educational division in company BooK s.r.o.. This monitoring will consist in setting up a new form of monitoring feedback mechanism with help of a made-to-measure web application created by me. The feedback check will reflect the customer’s satisfaction with services provided by this company as well as the evaluation of employees concerned. Creation of this new form of feedback was requested directly by the company management of BooK s.r.o. and the implementation and using itself will bring benefits the company primarily in automatization of the monitoring process and time factor. At the same time this application will serve as a tool for evaluation of satisfaction of the customers whose opinions are crucial for the company’s success and improvement of the standard of the provided services which will result in increasing the company’s competitiveness.
Proposal of Problem Solution of Monitoring of Employees
Krbková, Lenka ; MSc, Bedřich Snášel, (referee) ; Pokorný, Jiří (advisor)
My diploma thesis will serve as a manual for personnel managers in which forms and methods of control of employees will be summarized focused on mystery calling and mystery shopping. I will create a programme of fuzzy logic called OCCUPATIONAL INSPECTOR wherebly personnel managers will analyse and check their employees and therably save a part of financial resources which would otherwise be spent on external subject.
Biomarkers in children with periodic fever syndromes
Król, Petra ; Doležalová, Pavla (advisor) ; Šedivá, Anna (referee) ; Krbková, Lenka (referee)
- 4 - Abstract Introduction: Periodic fever syndromes are clinical entities classified as autoinflammatory diseases. The most of the periodic fever syndromes have genetic predisposition (monogenic periodic fever syndromes). PFAPA (Periodic Fever, Aphtous stomatitis, Pharyngitis a Adenitis) syndrome is an idiopathic disease with unknown aetiology. Results: In our study, we described the largest clinical series of patients with PFAPA syndrome from a single center. The laboratory results have confirmed uncomplicated course of PFAPA syndrome. In our measurements we observed significantly higher levels of serum cytokines (IL-1β and IFN-γ) during episodes of fever in PFAPA patients compared to the control group. Our measurements showed increased numbers of plasma cells in the peripheral blood of PFAPA patients. We have found increased levels of naïve CD4 and CD8 T cells and approximately 2-fold higher proportion of CD8 T cells in tonsils of PFAPA patients. Significant differences were also present at levels of IFN-γ, IL-1β, IL-6 and TNF-α in stimulated supernatants compared to supernatants from unstimulated peripheral blood from patients with PFAPA syndrome. Measurements of bacterial profile showed individual microbial profile in patients. Conclusion: Removal of the tonsillar tissue with the potential...
Diagnostics of neuroinfection caused by human herpesviruses using nucleic acid amplification methods
Labská, Klára ; Marešová, Vilma (advisor) ; Rožnovský, Luděk (referee) ; Krbková, Lenka (referee)
of thesis Diagnostics of neuroinfection caused by human herpesviruses using nucleic acid amplification methods author: MUDr. Klára Labská supervisor: doc. MUDr. Vilma Marešová, CSc. In recent years, the diagnosis of neuroinfections has undergone a shift towards molecular biology methods. Our research focused on the predictive value of the capture of herpesvirus (HV) DNA in cerebrospinal fluid. In the first study, we examined the presence of DNA neurotropic herpes viruses (HSV1, HSV2, VZV and HHV6) in cerebrospinal fluid in immunocompetent patients with laboratory-confirmed tick-borne meningoencephalitis and enterovirus meningitis and meningoencephalitis. The control group consisted of patients with proven absence of an inflammation in the cerebrospinal fluid. Patients were followed for 6 months. The course of the disease and its consequences, including laboratory tests, were compared between groups of patients with and without the presence of HV DNA. In the second study, we tried to demonstrate the presence of HSV1 DNA in cerebrospinal fluid during its symptomatic reactivation in patients with purulent meningitis. In our group of immunocompetent patients with non-purulent inflammation in the cerebrospinal fluid, the proportion of HV DNA positive patients reached 7.5% (13 out of 173), we also...
Biomarkers in children with periodic fever syndromes
Król, Petra ; Doležalová, Pavla (advisor) ; Šedivá, Anna (referee) ; Krbková, Lenka (referee)
- 4 - Abstract Introduction: Periodic fever syndromes are clinical entities classified as autoinflammatory diseases. The most of the periodic fever syndromes have genetic predisposition (monogenic periodic fever syndromes). PFAPA (Periodic Fever, Aphtous stomatitis, Pharyngitis a Adenitis) syndrome is an idiopathic disease with unknown aetiology. Results: In our study, we described the largest clinical series of patients with PFAPA syndrome from a single center. The laboratory results have confirmed uncomplicated course of PFAPA syndrome. In our measurements we observed significantly higher levels of serum cytokines (IL-1β and IFN-γ) during episodes of fever in PFAPA patients compared to the control group. Our measurements showed increased numbers of plasma cells in the peripheral blood of PFAPA patients. We have found increased levels of naïve CD4 and CD8 T cells and approximately 2-fold higher proportion of CD8 T cells in tonsils of PFAPA patients. Significant differences were also present at levels of IFN-γ, IL-1β, IL-6 and TNF-α in stimulated supernatants compared to supernatants from unstimulated peripheral blood from patients with PFAPA syndrome. Measurements of bacterial profile showed individual microbial profile in patients. Conclusion: Removal of the tonsillar tissue with the potential...
Electron microscopy in the diagnosis of viral gastroenteritis in children less than five years old.
Arientová, Simona ; Marešová, Vilma (advisor) ; Rožnovský, Luděk (referee) ; Krbková, Lenka (referee)
Acute gastroenteritis is one of the most frequent diseases in children worldwide and remains the main cause of childhood morbidity and mortality, particularly in developing countries. Each year as many as 1.5 million children less than first five years die in the world from acute gastroenteritis. Our study has been aimed at demonstrating of the main role of viruses in the aetiology of acute gastroenteritis in children less than five years old and at pointing out the diagnostic potential of electron microscopy in viral gastroenteritis. A prospective study was conducted to analyse the aetiology of diarrhoeal diseases in children less than five years of age admitted to the Department of Infectious Diseases of the Na Bulovce Hospital, Prague, between September, 2006 and June, 2009. All children were tested by faecal culture for bacterial aetiology and by latex agglutination and electron microscopy for viral aetiology. A total of 1059 children were included in the study. The mean age of children was 1.9 years and the mean length of hospitalisation was 5.2 days. An aetiological agent was detected in 1051 children (95.9%). A bacterial aetiology was found in 22 (2.1%) children, bacterial-viral co-infection was found in 183 (17.3%) patients and viruses were detected in 810 (76.5%) patients. The main causes of viral...
Use of statistical methods to evaluate activities in the language school Lingua Plus, ltd.
Krbková, Lenka ; MBA, Hana Neznalová, (referee) ; Kropáč, Jiří (advisor)
In my bachelor thesis I will analyse and evaluate work efficiency in the language school LinguaPlus, s.r.o. with the help of statistical methods. I will elaborate a model which would inform the company about its future activities development either under the same conditions, or after changing some characteristics. This model will be helpful for the company, will explain ineffective steps in the past, and precautions for the future.
Proposal of Methodology of Monitoring of Employees
Klimeš, Roman ; Krbková, Lenka (referee) ; Pokorný, Jiří (advisor)
My thesis will serve as a monitoring tool for the management of an educational division in company BooK s.r.o.. This monitoring will consist in setting up a new form of monitoring feedback mechanism with help of a made-to-measure web application created by me. The feedback check will reflect the customer’s satisfaction with services provided by this company as well as the evaluation of employees concerned. Creation of this new form of feedback was requested directly by the company management of BooK s.r.o. and the implementation and using itself will bring benefits the company primarily in automatization of the monitoring process and time factor. At the same time this application will serve as a tool for evaluation of satisfaction of the customers whose opinions are crucial for the company’s success and improvement of the standard of the provided services which will result in increasing the company’s competitiveness.

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