National Repository of Grey Literature 77 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Cardiometabolic risk assessment in patients with schizophrenia
Protopopová, Dita ; Masopust, Jiří (advisor) ; Doubek, Pavel (referee) ; Kašpárek, Tomáš (referee)
Cardiometabolic risk assessment in patients with schizophrenia SUMMARY The mortality due to cardiovascular (CV) disease is doubled in patients with schizophrenia compared to general population and they have a higher prevalence of modifiable CV risk factors. The causes of increased CV burden in schizophrenia include unhealthy life style and high prevalence of smoking. Schizophrenia itself is associated with changes in catecholamines, hormones and pro-inflammatory mediators with potential impact on cardiovascular system and its function. Antipsychotics can have a negative impact on various metabolic parameters and further increase CV risk in treated individuals. Both the diagnostics and treatment of CV health problems is insufficient in patients with schizophrenia. Regular monitoring of CV risk factors is recommended in clinical guidelines. However, based on studies in general population the traditional CV risk factors fail in prediction of coronary heart disease or other serious CV events in 25 to 50%. Endothelial function measurement seems to be a more sensitive tool to assess the risk of CV disease. Endothelial dysfunction (ED) represents a preclinical stage of atherosclerosis. In general population ED correlated with traditional CV risk factors and was superior to them in predicting future CV events. In...
Methods of electroconvulsive therapy augmentation
Buday, Jozef ; Anders, Martin (advisor) ; Kašpárek, Tomáš (referee) ; Dragašek, Jozef (referee)
In the theoretical part of our study, we provide a systematic review of contemporary methods (pharmacological and non-pharmacological) of ECT augmentation, as scored by three factors - manipulation of the seizure threshold, length of therapeutic seizures and the effect on ECT efficacy measured by the total number of ECT sessions and the rate/quantity of change on used objective/subjective scales. We also provide a summary of possible side effects and risks associated with the use of respective ECT augmentation methods. In the research part of our study, we explore the effect of high frequency transcranial magnetic stimulation on the respective ECT parameters, in a double blinded, placebo controlled, randomised study on a sample of 46 patients treated for a major depressive episode. During ECT titration, we registered a significantly lower seizure threshold in the experimental group, an average decrease in charge by 34.55%, from 34.23mC to 22.4mC, p< 0.001 (Wilcox test). We have not observed a significant effect of HF rTMS on the length of seizure or ECT efficacy. Our study confirms the hypothesis, that the application of HF rTMS briefly before an ECT session reduces the seizure threshold, which might be useful in certain types of patients.
Association between metabolic factors and structural brain changes in psychoses
Kolenič, Marián ; Hájek, Tomáš (advisor) ; Kašpárek, Tomáš (referee) ; Masopust, Jiří (referee)
Background: Schizophrenia (SZ) and bipolar disorders (BD) are often correctly diagnosed only years after the initial manifestations. Brain imaging may provide support for early differential diagnosis, but is complicated by marked heterogeneity of results between studies. Obesity, dyslipidemia and insulin resistance (IR) are frequent in psychiatric disorders and may contribute to brain alterations/heterogeneity. We studied BD and SZ in different stages of illness and specifically investigated the effects of metabolic parameters on brain structure and function. Methods: In Study 1 we used machine learning algorithm to estimate the individual brain age from MRI scans of 120 participants with first episode schizophrenia (FES) and 114 controls. We calculated the brain age gap (BrainAGE) score by subtracting the chronological age from the brain age. We also performed voxel-based morphometry (VBM) study to localize obesity or psychosis related pathology. In Study 2, we acquired biochemical and cognitive measures from 100 euthymic BD patients and explored the association between IR and memory. In Study 3, we explored differences in BrainAGE in early stages of SZ (43 participants) or BD (96 offspring of BD parents) and healthy controls (HC). In Study 4, we performed MRI cerebellar volume analyses on 648...
Using Advanced xBSD Based Servers for High School
Zadina, Martin ; Michal, Bohumil (referee) ; Kašpárek, Tomáš (advisor)
This work is about setting up Samba software on server with operating system from BSD family to primary domain controller rule in the high school computer network environment with Microsoft Windows stations. After introduction to Samba software there is examined problem of Windows network based on SMB protocol. There are described steps that are necessary to setup Samba software, disk sharing services, creation of user accounts and adding client stations to domain trust. At the next there is described problematic of network printing in the Windows environment, print servers and the solution with classical printing support in FreeBSD and CUPS printing support. In the next part there is described mass installation procedure of Windows stations with same hardware configuration. At the finish, there are noticed some tasks that are necessary for next operation of installed system.
Game Server Administration Client
Cigán, Tomáš ; Michal, Bohumil (referee) ; Kašpárek, Tomáš (advisor)
This bachelor thesis focuses on the description of game servers of the most common computer games. The details and differences between particular game servers as well as administration control are included. Also structure of plugins and plugin installation procedures for such servers is described in details. The main target of the thesis according to the previous research is to analyze and develop uniform system for controlling the game server and its plugins throw web application. At the end of the thesis there is detailed description of creating a new game server implementation support.
Traveling Salesman Problem - Parallel Methods Using SMP (OpenMP)
Hruška, Michal ; Jaroš, Jiří (referee) ; Kašpárek, Tomáš (advisor)
Thesis compares serial and parallel methods for solving traveling salesman problem. Some of the well-known heuristics are used. These have been tested for long hours. Time and space complexity are used as comparing measure. It was discovered that small part of ACO source code in parallel is going to speed up the code according to Amdahl's law.
Instant Messenging System
Fiedor, Jan ; Kašpárek, Tomáš (referee) ; Ráb, Jaroslav (advisor)
Nowadays many instant messenging clients exist. However, it is true, that many of them do not solve the security issues connected with communication, often deal with file transfer problems and are linked with specific protocol. This thesis is trying to find out the best solution of those problems and use it to develop secure and reliable client independent of concrete protocol.
Instant Messenging System
Gach, Marek ; Kašpárek, Tomáš (referee) ; Ráb, Jaroslav (advisor)
Present world of server applications is dynamically developing branch of IT. With multicore CPU appearance well designed multithreading applications gain additional performance. This thesis is trying to sketch out some basis of multithreaded application creation and synchronisation. Usage of this principles will help me to develop general-purpose parallel server core. Whole semantics of communication protocol for message sending is based on that core.
Embedded System for Water Level Monitoring
Hanák, Jiří ; Kašpárek, Tomáš (referee) ; Šimek, Václav (advisor)
This work is dealing with the design and implementation of an embedded water level monitoring system. The purpose of the system is to control the filling of a tank based on the water level. First of all, the attention is given to the survey of existing measurement techniques and selection of the appropriate sensing elements for a given scenario. In fact, the embedded system is using TFmini and JSN-SR04T-2.0 contactless sensors. The system is controlled by STM32F0 microcontroller from STMicroelectronics programmed in C using HAL abstraction layer. The measured results are sent via Wi-Fi SoC ESP8266EX to the Python server that is used for processing and demonstratiton purposes.
I/O Subsystem Optimalization Using SSD
Bělousov, Petr ; Chalupníček, Kamil (referee) ; Kašpárek, Tomáš (advisor)
The bachelor thesis examines IO subsystem optimization using SSD cache to speed up HDDs. I examined possible server loads and identified those that are suitable for caching. In the first part I introduce 2 caching solutions, LVM cache and B-cache with their management capabilities and 2 filesystems Ext4 and XFS. In the second part IO performance of LVM cache and B-cache with Ext4 and XFS filesystem is benchmarked and compared to an uncached HDD array.

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