National Repository of Grey Literature 6 records found  Search took 0.01 seconds. 
Psoriasis and Its Comorbidities. Mutual Relationship of the Disease and the Process of Aging.
Borský, Pavel ; Fiala, Zdeněk (advisor) ; Müllerová, Dana (referee) ; Dlouhý, Pavel (referee)
Psoriasis vulgaris (psoriasis) is an autoimmune disease that primarily affects the skin. The pathogenesis of psoriasis involves a combination of genetic and epigenetic modifications with a significant influence of environmental factors. The disease is characterized by papulosquamous lesions with hyperproliferation of keratinocytes, angiogenesis and dysregulation of the normal immune response leading to chronic inflammation. Excessive activation of parts of the adaptive immune system is thought to be a central factor in the pathogenesis of psoriasis. More severe forms of psoriasis tend to be associated with other diseases (comorbidities). These include metabolic and cardiovascular diseases, psoriatic arthritis, Crohn's disease and psychiatric disorders or uveitis. Many of these comorbidities show a significant association with age (the biological process of human aging). Aging is a process of gradual decline in the body's abilities and functional capabilities. It is a universal process with a considerable degree of variability that is characteristic of all higher animals. Among the theories describing aging, the theory of accumulation of damage, which integrates the previously known mechanisms of aging, is currently dominant. The theory is based on the fact that during pathophysiological processes,...
Business plan of physical shop founding in extension to existing e-shop
Šťastný, Jan ; Borský, Pavel (referee) ; Heralecký, Tomáš (advisor)
A plan of opening a physical shop (a low-cost expediting point) as an extension of currently runnning electronic shop is the main focus of this thesis. The analysis of demographic population data, market situation (supply/demand), internal and external corporate enviroment is presented. An attempt is made to provide the answer for the question whether proposed enterprise is pursuable or not. The results of analytic part are used for the shop building locality selection. Furthermore, corporate history, financial and business planning, marketing strategy, organizational structure are provided in practical part of this thesis. Final part is providing the evaluation and selection of the shop founding locality.

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