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The role of galectins in skin wound healing
Přitasilová, Adriena ; Sedlář, Antonín (advisor) ; Zimolová, Miluše (referee)
Galectins are proteins that bind β-galactosides through their Carbohydrate Recogni- tion Domain (CRD). There have been 16 types discovered in mammals, with only 4 not found in humans. They are present in various cell types and tissues and are involved in numerous physiological functions, such as apoptosis and cell proliferation, as well as in several pathological conditions, including inflammatory skin diseases. For example, anti- bodies against galectin-3 cause skin inflammation in lupus erythematosus. During wound healing in a pig model experiment, an upregulation of galectin-1 in the dermis and its neo-expression in the epidermis were observed, along with an increased level of galectin- 7. Galectin-1 plays a significant role especially in the formation of hypertrophic scars (HTS), which result from excessive collagen deposition during wound healing. HTS are erythematous and thick, causing cosmetic defects that could be addressed by modulating galectin activity during healing. Therefore, the aim of this bachelor thesis is to conduct a systematic literature review on the role of galectins in wound healing, considering both their positive and negative effects, with particular emphasis on the role of galectins and their ligands in the formation and regression of hypertrophic and keloid scars.
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Business Plan
Zimolová, Miluše ; Skoumal, Zdeněk (referee) ; Bayerová, Vladimíra (advisor)
The aim of my Master thesis “Business Plan Company“ is to provide a solution for a successful develop a small company, which will have a real potential to find its stable position on the current market. My Master thesis consists of a theoretical part, problem analysis and my own proposal of the solution. The theoretical part deals with the key findings and solutions, which are further applied in the next part of my work. Analysis is focused on prezent and future company environment. Concrete recommendations have been formulated on the basis of analysis conclusions. The final proposal is formulated into a komplex procedure, which provides the way to reach company development.
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Business Plan
Zimolová, Miluše ; Skoumal, Zdeněk (referee) ; Bayerová, Vladimíra (advisor)
The aim of my Master thesis “Business Plan Company“ is to provide a solution for a successful develop a small company, which will have a real potential to find its stable position on the current market. My Master thesis consists of a theoretical part, problem analysis and my own proposal of the solution. The theoretical part deals with the key findings and solutions, which are further applied in the next part of my work. Analysis is focused on prezent and future company environment. Concrete recommendations have been formulated on the basis of analysis conclusions. The final proposal is formulated into a komplex procedure, which provides the way to reach company development.
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