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Serum concentration of vitamin D in patients with femoral neck fracture
Matoušková, Karolína ; Wenchich, László (advisor) ; Zikán, Vít (referee)
Vitamin D significantly affects metabolism of the bone tissue. It keeps homeostasis of calcium and phosphor and thus contributes to healthier mineralization of bones. Lack of those substances pertains to risk factors for development of osteoporosis and subsequent complications during possible downfalls and fractures. The role of vitamin D in bone disease has been increasing in recent years, but its importance in the early post-fracture period is not yet fully understood. This thesis is a prospective study of metabolism of vitamin D and its metabolites in post-operative stage of patients with femoral neck fractures. It is a basic quantitative research, where received data are analysed. Blood samples obtained from a total of 18 patients, whose blood was taken on the day of surgery and 6 weeks after surgery (± 1 week), were used as material. Resulted values of 25-OH vitamin D increased from 23,02 ± 16,02 nmol/l to 25,75 ± 16,30 nmol/l (diameter ± standard deviation). In contrast, 1,25-(OH)2 vitamin D decreased from 76,81 ± 41,84 pmol/l to 55,88 ± 26,34 pmol/l. Statistically significant results at a significance level of p≤0,05 were only observed for parathyroid hormone (PTH), with values decreasing from 6,31 ± 3,95 pmol/l to 3,96 ± 2,25 pmol/l. Vitamin D examinations in our patients showed reduced...
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