Home > Search Results: Vavrysová, Helena
Search:
Search Tips :: Advanced Search
Search collections:
Sort by: Display results: Output format:
National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
The physico-chemical characterization of prospective transdermal absorption enhancers.
 Vavrysová, Helena ; Zbytovská, Jarmila (advisor) ; Vávrová, Kateřina (referee)
THE PHYSIOCHEMICAL CHARACTERISATION OF POSSIBLE ENHANCERS FOR ABSORPTION The work is deal with studies of lipid and characterisation of the thermotopic behaviour of selected possible enhancers for transdermal absorption. The thermotropic behaviour was observed by combination DSC and IR spectroscopy of five synthetic compounds with similar structure as skin ceramides. We can deduce that all studied enhancers are highly ordered structures with high numer of trans conformers and triclinical lipid chain packing. With increased temperatur growth number of gauche conformers and increase fluidity of lipid chain. At the same time dissapear hydrogen bounds which form on the polar heads between lipid chains. Temperature differencies of phase transitions of measuring compounds is considerable. It can be caused insuficient heating of ATR crystal but exists linear dependence of correlation. With increased temperature growth measurement error. This dependence can be used for other measurements.
Detailed record
Study of the Termotropic Behaviour of Short-chain Ceramid Analogues
 Vavrysová, Helena ; Zbytovská, Jarmila (advisor) ; Doležal, Pavel (referee)
Ceramides of stratum corneum (SC) play a crucial role in maintaining the barrier function of the skin. This work deals with series short-chain analogues of ceramides with structure identical to naturally occuring ceramide NS, acyl chain length from 2 to 12. Acyl chain length is very important for barrier properties. Ceramides with chain length 4-8C lose barrier function, conversely were able to increase skin peremability. Ceramides with 2 and 12C showed no increase in permeability. Calorimetric and infrared spectroscopic measuring data were used for studying thermotropic phase behaviour analogues of ceramides and compared to the physiological cermide NS. At physiological temperatures, all crystalline phases of ceramides exhibit lamellar structures with highly ordered hydrocarbon chains. Structure-activity relationships and potential permeable aktivity of these ceramides were observed. Short-chain ceramides do not act as natural ceramides and their biological activity has been widely investigated.
Detailed record
The physico-chemical characterization of prospective transdermal absorption enhancers.
 Vavrysová, Helena ; Zbytovská, Jarmila (advisor) ; Vávrová, Kateřina (referee)
THE PHYSIOCHEMICAL CHARACTERISATION OF POSSIBLE ENHANCERS FOR ABSORPTION The work is deal with studies of lipid and characterisation of the thermotopic behaviour of selected possible enhancers for transdermal absorption. The thermotropic behaviour was observed by combination DSC and IR spectroscopy of five synthetic compounds with similar structure as skin ceramides. We can deduce that all studied enhancers are highly ordered structures with high numer of trans conformers and triclinical lipid chain packing. With increased temperatur growth number of gauche conformers and increase fluidity of lipid chain. At the same time dissapear hydrogen bounds which form on the polar heads between lipid chains. Temperature differencies of phase transitions of measuring compounds is considerable. It can be caused insuficient heating of ATR crystal but exists linear dependence of correlation. With increased temperature growth measurement error. This dependence can be used for other measurements.
Detailed record

Interested in being notified about new results for this query?
Subscribe to the RSS feed.
Digital Repository :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.2
Maintained by admin.invenio@techlib.cz
This site is also available in the following languages:
Česky  English