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	Influence of pyridoxalisonicotinoyl hydrazone on spectral properties of alanine aminotransferase Vančurová, Kamila ; Dršata, Jaroslav (advisor) ; Skálová, Lenka (referee) The aim of this study was to examine the influence of pyridoxalisonicotinoylhydrazone (PIH) on alanine aminotransferase (EC 2. 6. 1. 2.). Alanine aminotransferase belongs to the group of pyridoxal enzymes. Pyridoxal-5'-phosphate is a prosthetic group of these enzymes. There is a similarity to the structure of pyridoxal and isoniazide in the formula of pyridoxalisonicotinoylhydrazone. PIH has been investigated for its potential iron-chelating activity. There are also studies about PIH's protective effect against cardiotoxicity caused by the treatment with anthracyclines. Cardiotoxicity is the main harmful side effect of the anthracycline medication. There is a part which is similar to pyridoxalphosphate in the structure of PIH. That's why the influence of PIH on spectral properties of pyridoxal enzymes was studied. For this spectral study we chose transaminases as suitable pyridoxal enzymes. During the catalyzed reaction they change their absorption spectra. Most common transaminase aspartate aminotransferase (AST) was not optimal for this study. AST absorbs in the same region where PIH does. Alanine aminotransferase absorbs in the spectrum separately and therefore it was convenient for this study. UV-VIS spectra and circular dichroism (CD) spectra were measured. The ability of providing CD spectra is the... Detailed record
	Influence of pyridoxalisonicotinoyl hydrazone on spectral properties of alanine aminotransferase Vančurová, Kamila ; Dršata, Jaroslav (advisor) ; Skálová, Lenka (referee) The aim of this study was to examine the influence of pyridoxalisonicotinoylhydrazone (PIH) on alanine aminotransferase (EC 2. 6. 1. 2.). Alanine aminotransferase belongs to the group of pyridoxal enzymes. Pyridoxal-5'-phosphate is a prosthetic group of these enzymes. There is a similarity to the structure of pyridoxal and isoniazide in the formula of pyridoxalisonicotinoylhydrazone. PIH has been investigated for its potential iron-chelating activity. There are also studies about PIH's protective effect against cardiotoxicity caused by the treatment with anthracyclines. Cardiotoxicity is the main harmful side effect of the anthracycline medication. There is a part which is similar to pyridoxalphosphate in the structure of PIH. That's why the influence of PIH on spectral properties of pyridoxal enzymes was studied. For this spectral study we chose transaminases as suitable pyridoxal enzymes. During the catalyzed reaction they change their absorption spectra. Most common transaminase aspartate aminotransferase (AST) was not optimal for this study. AST absorbs in the same region where PIH does. Alanine aminotransferase absorbs in the spectrum separately and therefore it was convenient for this study. UV-VIS spectra and circular dichroism (CD) spectra were measured. The ability of providing CD spectra is the... Detailed record
	Interaction of aromatic L-amino acid decarboxylase with coenzyme derivate in vitro Vančurová, Kamila ; Dršata, Jaroslav (advisor) ; Kvasničková, Eva (referee) Detailed record

See also: similar author names
2	VANČUROVÁ, Karolína
8	VANČUROVÁ, Kateřina
2	Vančurová, Karolína
8	Vančurová, Kateřina
1	Vančurová, Klára
1	Vančurová, Kristýna

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