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Caseinomacropeptide biological properties
Vašíčková, Klára ; Potůčková, Miroslava (advisor) ; Michaela, Michaela (referee)
The aim of the bacherol thesis was to summarize the current knowledge about biological properties of caseinomacropeptide. Caseinomacropeptide is hydrophilic, mostly glycosylated peptide which commes from kappa-casein during its chymosine proteolysis.
Polypeptide has a lot of interesting functional and biological properties thanks which has a wide potential for food industry and development of new products with added value. Its valuable physico-chemical properties include surface activity (emulsifying and foaming properties), gel-forming and adsorption properties, thermo- and acidobasic stability. From the biological effects may be mentioned antibacterial, anticariogenic, antiviral, dietary, effects on the gastrointestinal tract, hypoallergenic and immunomodulatory properties and prebiotic.
In many studies was observed that the higher biological activity of caseinomacropeptide (native or hydrolysed forms) is connected with its glycosylation. One of the most important parameters is also sialic acid content. Good bioactive properties also demonstrated polypeptide conjugates with galactooligosaccharides. Antibacterial effect of caseinomacropeptide was recorded for example against pathogenic strains of Escherichia coli ETEC K88, Salmonella enterica subsp. enterica serotyp typhimurium CECT 443 a Listeria monocytogenes CECT 935. Polypeptide acted as prebioticum for Bifidobacterium animalis subsp. lactis BB12, Bifidobacterium bifidum CCDM 94, Bifidobacterium thermophilum RB 267, Lactobacillus bulgaricus ATCC 7517, Lactococcus lactis subsp. Lacti and Lactobacillus rhamnosus RW-959-M. Anticariogenic properties of caseinomacropeptide were successfully used against selected strains of Streptococcus mutans, sanguis and sorbinus and model hydroxyapatite system. Glycosylated forms of polypeptide also stimulated gastric and pancreatic enzymes and cholecystokinin secretion but any positive influence of caseinomacropeptide on appetite and hunger suppressing and food and energy intake decreasing has not been observed.
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