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Tumor markers at OKB Pelhřimov Hospital - methods of assessment, clinical significance.
VACÍKOVÁ, Kateřina
Tumour diseases are the most common cause of death in the Czech Republic after heart and vessel diseases. Each year a number of new cancer patients are diagnosed and accepted for treatment. Determining the level of tumour markers is an integral part of screening methods for early detection of the disease, diagnosis and control of the course of treatment. Currently, no universal marker is available, so more markers of cancer, whose specificity and sensitivity are overlapping, are determined in the analysis. In the theoretical part, the thesis deals with a general description of tumour diseases. Another part is devoted to tumour markers, characteristics, evaluation of the results of the examination and their division. Subsequently individual tumour markers investigated at the Department of Clinical Biochemistry of Pelhřimov Hospital, semi-budgetary organization, are described. The practical part is devoted to the methods of tumour marker determination at the Department of Clinical Biochemistry ofPelhřimov Hospital, semi-budgetary organization. It is followed by the description of the principle of tumour marker determination on the Cobas e601 analyser. The experimental part is devoted to the statistics of tumour markers for individual years (2015-2017) obtained from the Department of Clinical Biochemistry of Pelhřimov Hospital, semi-budgetary organization. Furthermore, in the experimental part I deal with patients and their evaluation of the results. The aim of the bachelor thesis is to prepare a summary of the most important and most used tumour markers, a brief characterization and a description of the importance for clinical practice. The thesis also presents laboratory methods of their determination including analytical parameters, preanalytical requirements and the evaluation of tumour marker results. At the end of the thesis statistical data obtained at the workplace of OKB (the Department of Clinical Biochemistry) and RTO (the Department of Radiology) of Pelhřimov Hospital, semi-budgetary organization, are presented.
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