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Study of anticancer and antimetastatic activity of a novel platinum complex containing protein kinase inhibitor and STAT inhibitor
 Urbaníková, Lucie ; Lišková,, Barbora (referee) ; Marková,, Lenka (advisor)
Tumor diseases continue to pose a challenge in the search for effective therapy. One option is chemotherapy, which utilizes newly synthesized and tested platinum complexes with potential in cancer treatment. The aim of this study was to investigate the antiproliferative activity of a new platinum complex, its penetration and accumulation in tumor cells, as well as its antimigratory properties. Antiproliferative activity was assessed using the MTT test and CellTiterGLo assay. Complex penetration and accumulation were studied using inductively coupled plasma mass spectrometry (ICP-MS). Antimigratory properties were examined through scratch assays. The complex demonstrated effective antiproliferative activity, penetration, and accumulation in tumor cells. Additionally, its antimigratory properties were confirmed.
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1 Urbaníková, Lea
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