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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Gamma-delta T lymphocytes in adipose tissue
 Sztoláriková, Adéla ; Krulová, Magdaléna (advisor) ; Pačes, Jan (referee)
 T lymphocytes are a unique type of T lymphocytes which, because of their innate-like qualities, belong to the so-called innate lymphocytes. Although they are a relatively rare population of T lymphocytes in peripheral blood, they are enriched in many peripheral tissues where they participate in immune responses to infectious pathogens and cell transformation. In addition, they play a role in the development of several autoimmune disorders. Recently, non- immune functions of  T lymphocytes in tissue repair and tissue homeostasis have also been emphasized. This work focuses on the characterization of  T lymphocytes, especially those residing in adipose tissue.  T lymphocytes regulate adipose tissue homeostasis and overall energy metabolism. The roles of  T lymphocytes under physiological and non-physiological conditions are described, including their impact on the development of obesity and metabolic syndrome. The possible applications of these lymphocytes in the treatment of these diseases are also briefly mentioned.
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