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Trends in incidence of Tuberculosis and Nontuberculous Mycobacterial Infections in years 2001-2020
Doležalová, Karolína ; Göpfertová, Dana (advisor) ; Skřičková, Jana (referee) ; Svatoň, Martin (referee)
Trends in incidence of tuberculosis and non-tuberculous mycobacteriosis in children and adolescents in Czech republic in years 2001-2020 BCG vaccination programs were introduced into Czechoslovakia more than 60 years ago under an entirely different epidemiological situation than that of today. Compulsory mass BCG vaccination was abolished in November 2010 and changed to a selective vaccination program for infants at high risk of contracting tuberculosis. This work wants to ascertain the risk of tuberculosis and non-tuberculous mycobacterial infection in 10 years following the change of the vaccination program and a comparison with the same period of mass BCG vaccination. The design of this work is a descriptive study, comparison, and statistical analysis of data for the period 2001-2020 about cases of tuberculosis and mycobacteriosis as reported in the Tuberculosis Register. The conclusions are that the trend of TB incidence in children in both compared periods is identical and statistically significantly decreasing (p <0,001). The trend of incidence of NTM cervical lymphadenitis in children is in the first period degressive and non-significant (p=0,561). However, in the second period, the trend is significantly increasing (p <0,001), in every, compared two subsequent years is an increase of 8 %....
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Clinical use of gene expression of RNA in non-small cell lung carcinoma (NSCLC)
Svatoň, Martin ; Pešek, Miloš (advisor) ; Salajka, František (referee) ; Skřičková, Jana (referee)
The clinical use of determination of gene expression of RNA in non-small cell lung cancer (NSCLC) Abstract Introduction Non-small cell lung cancer (NSCLC) belongs to the most frequent causes of cancer deaths worldwide. Chemotherapy (CHT) has still (except pemetrexed) administered according to stages and patients comorbidities, without the use of other predictive markers. It results into only low objective therapeutical response that differs in indivial patients without more clearly known causes. Aims The aim of our research was to find possible predictive markers in the form of mRNA or miRNA, which would help to reduce the effect of NSCLC / CHT for selected groups of patients. Methods In three groups of patients (42 patients with radically resected adenocarcinomas stage 1; 90 patients with NSCLC who have undergone surgical resection and 59 of them consequently adjuvant CHT; 81 patients palliatively treated in combination platinum derivative + paclitaxel/gemcitabine +/- sequential radiotherapy with advanced squamous NSCLC stages 3B, 4), we examined the effect of expression of mRNA and miRNA until relapse (DFI) / progression (PFS) and overall survival (OS). Expressions were determined with the real-time PCR methodology using UPL probes. Statistical analysis used cox regression model and Kaplan - Meier...
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Clinical use of gene expression of RNA in non-small cell lung carcinoma (NSCLC)
Svatoň, Martin ; Pešek, Miloš (advisor) ; Salajka, František (referee) ; Skřičková, Jana (referee)
The clinical use of determination of gene expression of RNA in non-small cell lung cancer (NSCLC) Abstract Introduction Non-small cell lung cancer (NSCLC) belongs to the most frequent causes of cancer deaths worldwide. Chemotherapy (CHT) has still (except pemetrexed) administered according to stages and patients comorbidities, without the use of other predictive markers. It results into only low objective therapeutical response that differs in indivial patients without more clearly known causes. Aims The aim of our research was to find possible predictive markers in the form of mRNA or miRNA, which would help to reduce the effect of NSCLC / CHT for selected groups of patients. Methods In three groups of patients (42 patients with radically resected adenocarcinomas stage 1; 90 patients with NSCLC who have undergone surgical resection and 59 of them consequently adjuvant CHT; 81 patients palliatively treated in combination platinum derivative + paclitaxel/gemcitabine +/- sequential radiotherapy with advanced squamous NSCLC stages 3B, 4), we examined the effect of expression of mRNA and miRNA until relapse (DFI) / progression (PFS) and overall survival (OS). Expressions were determined with the real-time PCR methodology using UPL probes. Statistical analysis used cox regression model and Kaplan - Meier...
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