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The influence of polymorphisms of selected genes on human chronotype
Vernerová, Klára ; Šolc, Roman (advisor) ; Spurná, Zuzana (referee)
Circadian rhythm refers to wide scale of biological mechanisms which change periodically, for example changes in hormonal secretion, changes in body temperature and the sleep cycle. It is a self-sustaining system which repeats roughly every 24hours. Circadian rhythm is designed to response and synchronize with external environment to effectively react to external changes. Yet, it is able to maintain its rhythm despite the absence of any outer signals. This applies to humans as well, although the timing of "the inner clock" is not the same for every individual and can vary a lot. Chronotype describes an individual setting of physiological, biochemical and psychological variables, which closely depend on the sleep cycle. The timing of the sleep cycle along with the preferred time of activity reflects the chronotype of the individual. The genetic effect account for about one-half of the chronotype, yet to now days the mechanisms or precise locuses are still unclear. The aim of this diploma thesis is to select relevant polymorphisms of clock genes and other relevant genes and test their association with chronotype. Based on the results obtained from MEQ questionnaire, we received saliva samples from participants with extreme chronotypes. We isolated and sequenced this DNA samples using classical...
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Economic analysis of Presbeton Nova Ltd
Spurná, Zuzana ; Doláková, Helena (advisor) ; Vyroubal, Vojtěch (referee)
This thesis deals with the economic analysis of the company Presbeton Nova Ltd. The main target is to assess the economic situation in the company and thereby to help management with the decision about future development. In the theoretic part there are described methods related to this area. Applied part devotes to the application methods -- analysis of production, financial analysis and Economic Value Added. The CAPM (capital asset pricing model) is being used to calculate costs of Equity. The cost of foreign capital is calculated according to the trend of rate 3M PRIBOR.
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Strategická analýza společnosti Presbeton Nova, s.r.o.
Spurná, Zuzana ; Středová, Ivana (advisor)
Práce se zabývá strategickou analýou společnosti Presbeton Nova, s.r.o., která je rozdělena na externí a interní část. Pomocí SWOT analýzy určuje, jaké faktory mají na podnik největší vliv. Dále hodnotí dosavadní strategii společnosti podle čtyř konkurenčních strategií a v závěru nástíní možná strategická doporučení, která vyplynou ze samotného provedení strategické analýzy.
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