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Preclinical models of brain metastases
Smetana, Tadeáš Karel ; Výmolová, Barbora (advisor) ; Sedlák, František (referee)
Malignant diseases are the second most common cause of death in the Czech Republic. One of the serious complications of these diseases are brain metastases, the incidence of which is increasing due to the improvement of diagnostics and advances in the therapy of the primary tumors. However, the treatment of brain metastases is complicated by their localization and the presence of the blood-brain barrier, which affects the efficacy of many drugs. Preclinical models are essential for better understanding of the biological properties of metastasizing cells, their relationship to the unique microenvironment of brain tissue, and for testing new therapeutic approaches. This bachelor thesis focuses on in vitro and in vivo systems modelling key aspects of brain metastasis biology and their use in testing new therapeutic approaches.

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4 Smetana, Tomáš
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