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Determining the compression behaviour of microcrystalline cellulose and magnesium stearate
Smékalová, Petra ; Řehula, Milan (advisor) ; Špaček, Vladimír (referee)
This thesis deals with the characterisation of a specific compression process by monitoring the viscoelastic properties of pressed material. The theoretical part of the thesis describes the substances - microcrystalline cellulose and magnesium stearate. It also describes methods for the assessment of tablet viscoelasticity using the force-displacement diagram and factors influencing the viscoelasticity of tablets. The aim of the experimental part of the work is to characterise the viscoelastic properties of microcrystalline cellulose as well as a mixture of microcrystalline cellulose and magnesium stearate lubricant of various lubricant concentrations using the force-displacement diagram and calculation of tablet relaxation. Tablets were pressed from a mixture of aggregates of microcrystalline cellulose and magnesium stearate lubricant using a T1-FRO 50 machine at 11 molding pressures in the range of 1,9 -113,0 MPa with lubricant concentration in the range of 0 % - 2,50 %. The height and diameter of each tablet were measured immediately after pressing and the measurements were repeated 24 hours later. Measurements determined viscoelastic parameters E1, E2, E3, Elis, and P1, and the volumes of the tablets, both at time 0 and after 24 hours. The result of the study was to determine the effect of...
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Determining the compression behaviour of microcrystalline cellulose and magnesium stearate
Smékalová, Petra ; Řehula, Milan (advisor) ; Špaček, Vladimír (referee)
This thesis deals with the characterisation of a specific compression process by monitoring the viscoelastic properties of pressed material. The theoretical part of the thesis describes the substances - microcrystalline cellulose and magnesium stearate. It also describes methods for the assessment of tablet viscoelasticity using the force-displacement diagram and factors influencing the viscoelasticity of tablets. The aim of the experimental part of the work is to characterise the viscoelastic properties of microcrystalline cellulose as well as a mixture of microcrystalline cellulose and magnesium stearate lubricant of various lubricant concentrations using the force-displacement diagram and calculation of tablet relaxation. Tablets were pressed from a mixture of aggregates of microcrystalline cellulose and magnesium stearate lubricant using a T1-FRO 50 machine at 11 molding pressures in the range of 1,9 -113,0 MPa with lubricant concentration in the range of 0 % - 2,50 %. The height and diameter of each tablet were measured immediately after pressing and the measurements were repeated 24 hours later. Measurements determined viscoelastic parameters E1, E2, E3, Elis, and P1, and the volumes of the tablets, both at time 0 and after 24 hours. The result of the study was to determine the effect of...
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