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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Wound repair and diabetic wound defects
 Slavkovský, Rastislav ; Kanta, Jiří (advisor) ; Dvořánková, Barbora (referee) ; Veverková, Lenka (referee)
of dissertation thesis WOUND REPAIR AND DIABETIC WOUND DEFECTS. Rastislav Slavkovský Impaired diabetic wound healing is an important current medical issue, mainly concerning patients recovering from complicated operations or patients with ulcers on their feet. Hyaluronan (HA) plays an important role in the repair of damaged skin and has been used for the treatment of wounds. A mixture of high molecular weight HA with the antiseptic iodine complex KI3 (Hyiodine) was reported to accelerate wound healing in patients with diabetes and patients after surgery. We investigated how this mixture affects wound contraction, granulation tissue (GT) and wound edges in excision skin wounds in rats. Hyiodine was applied to full- thickness wounds made on the back of rats. The areas of the contracting wounds were calculated from digital photographs. The migrating edges of the wound were studied by histological methods. The properties of GT were studied in wounds in which contraction was prevented by the insertion of plastic rings. The effects of Hyiodine were compared with those of high molecular weight HA, low molecular weight HA and KI3 solution. Hyiodine accelerated wound contraction significantly in the first 5 days of healing. On day 3, Hyiodine-treated wounds had reduced to 63% of the original area, whereas...
Detailed record
Wound repair and diabetic wound defects
 Slavkovský, Rastislav ; Kanta, Jiří (advisor) ; Dvořánková, Barbora (referee) ; Veverková, Lenka (referee)
of dissertation thesis WOUND REPAIR AND DIABETIC WOUND DEFECTS. Rastislav Slavkovský Impaired diabetic wound healing is an important current medical issue, mainly concerning patients recovering from complicated operations or patients with ulcers on their feet. Hyaluronan (HA) plays an important role in the repair of damaged skin and has been used for the treatment of wounds. A mixture of high molecular weight HA with the antiseptic iodine complex KI3 (Hyiodine) was reported to accelerate wound healing in patients with diabetes and patients after surgery. We investigated how this mixture affects wound contraction, granulation tissue (GT) and wound edges in excision skin wounds in rats. Hyiodine was applied to full- thickness wounds made on the back of rats. The areas of the contracting wounds were calculated from digital photographs. The migrating edges of the wound were studied by histological methods. The properties of GT were studied in wounds in which contraction was prevented by the insertion of plastic rings. The effects of Hyiodine were compared with those of high molecular weight HA, low molecular weight HA and KI3 solution. Hyiodine accelerated wound contraction significantly in the first 5 days of healing. On day 3, Hyiodine-treated wounds had reduced to 63% of the original area, whereas...
Detailed record

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3 Slavkovský, Radim
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