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The importance of genetic testing in prevention of bleeding complications of invasive procedures in cardiology
Sionová, Magdalena ; Moťovská, Zuzana (advisor) ; Ošťádal, Petr (referee) ; Pudil, Radek (referee)
Background: Periprocedural bleeding is the most common complication related to coronary angiography (CAG) and percutaneous coronary intervention (PCI) and it is associated with worse short-term and long-term prognosis. Determining risk factors and genetic variations associated with increased bleeding risk may improve use of avoidance bleeding strategies in prevention of bleeding. Aim: The aim of our study was to a) identify independent risk factors (of the baseline characteristics, clinical, laboratory a procedural data) associated with a higher risk of periprocedural bleeding b) to validate predictive value of CRUSADE and NCDR bleeding risk stratification algorithms c) to analyze the association between the presence of selected single nucleotide polymorphisms of key platelet proteins (GPIa, GPVI, P2Y12, COX-1) and the risk of periprocedural bleeding. Methods: The study included 73 patients with acute or chronic ischemic heart disease who developed bleeding complication within 30 days after invasive procedure (CAG/PCI). The control group consisted of 331 patients without bleeding. Baseline characteristics, clinical state at admission, laboratory data (creatinine, blood count, INR) and procedural data were evaluated. The CRUSADE and NCDR algorithms for bleeding risk were retrospectively applied on both...
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The importance of genetic testing in prevention of bleeding complications of invasive procedures in cardiology
Sionová, Magdalena ; Moťovská, Zuzana (advisor) ; Ošťádal, Petr (referee) ; Pudil, Radek (referee)
Background: Periprocedural bleeding is the most common complication related to coronary angiography (CAG) and percutaneous coronary intervention (PCI) and it is associated with worse short-term and long-term prognosis. Determining risk factors and genetic variations associated with increased bleeding risk may improve use of avoidance bleeding strategies in prevention of bleeding. Aim: The aim of our study was to a) identify independent risk factors (of the baseline characteristics, clinical, laboratory a procedural data) associated with a higher risk of periprocedural bleeding b) to validate predictive value of CRUSADE and NCDR bleeding risk stratification algorithms c) to analyze the association between the presence of selected single nucleotide polymorphisms of key platelet proteins (GPIa, GPVI, P2Y12, COX-1) and the risk of periprocedural bleeding. Methods: The study included 73 patients with acute or chronic ischemic heart disease who developed bleeding complication within 30 days after invasive procedure (CAG/PCI). The control group consisted of 331 patients without bleeding. Baseline characteristics, clinical state at admission, laboratory data (creatinine, blood count, INR) and procedural data were evaluated. The CRUSADE and NCDR algorithms for bleeding risk were retrospectively applied on both...
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