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National Repository of Grey Literature

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Pyrazine derivates as potential drugs IV. Schürger, Oliver ; Doležal, Martin (advisor) ; Miletín, Miroslav (referee) Oliver Schürger: Pyrazine derivates as potential drugs IV. Keywords : tuberculosis, Mycobacterium tuberculosis, Directly Observed Treatment Strategy, Multi drug Resistence, pyrazinamide Abstract of Diploma Thesis: This review is about worldwide problem of tuberculosis and about new trends in its treatment. Also chemical search about methods of preparing substituted amides of pyrazinecarboxylic acid and pyrazine-2,5-dinitril was done. All products were characterized by melting point, TLC, elemental analysis, IR analysis, log P and some of the final products have also 1 H, 13 C NMR spectra made. Products were not been tested in biological studies yet. Detailed record

Pyrazine derivates as potential drugs IV. Schürger, Oliver ; Doležal, Martin (advisor) ; Miletín, Miroslav (referee) Oliver Schürger: Pyrazine derivates as potential drugs IV. Keywords : tuberculosis, Mycobacterium tuberculosis, Directly Observed Treatment Strategy, Multi drug Resistence, pyrazinamide Abstract of Diploma Thesis: This review is about worldwide problem of tuberculosis and about new trends in its treatment. Also chemical search about methods of preparing substituted amides of pyrazinecarboxylic acid and pyrazine-2,5-dinitril was done. All products were characterized by melting point, TLC, elemental analysis, IR analysis, log P and some of the final products have also 1 H, 13 C NMR spectra made. Products were not been tested in biological studies yet. Detailed record

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