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National Repository of Grey Literature

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Characteristics of phytoplankton in production ponds Protected Landscape Area Třeboňsko SKÁCELOVÁ, Kateřina Detailed record

Cytotoxicity of bentic and periphyton cyanobacteria SKÁCELOVÁ, Kateřina This study is focused on assessment of cytotoxic activity of 14 strains of benthic cyanobacteria against HeLa cell line. Extracts of the strains generating strong cytotoxicity were analyzed and fractionated with HPLC-MS, in order to determine active fractions. Mechanisms of effect on the cells were investigated using immunofluorescent staining. Two out of 14 studied strains exhibited strong cytotoxic activity. Extract of Cylindrospermum sp. CY OM contains active fraction inducting apoptosis and also a fraction affecting adhesion of cells. Activity of Anabaena oscillarioides HINDAK 1984/43 strain was caused by two cytotoxic fractions, in one of them a new linear peptide was discovered. Detailed record

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1	Skácelová, Karolína

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