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Biotransformation, disposition and toxicological detection of psychedelic phenylalkylamine drugs of abused
 Rohanová, Miroslava ; Balíková, Marie (advisor) ; Martásek, Pavel (referee) ; Květina, Jaroslav (referee)
Background: New synthetic drugs known for their psychotropic effects (stimulating, psychedelic and enthactogenic) are drugs of abuse causing number of health and social issues. Together with their consumption the cases of intoxication have increased and therefore the requirements for the differential diagnosis and appropriate therapy have arisen. The aim of the submitted work has been to investigate the disposition and biotransformation profiles of selected synthetic phenylalkylamine derivatives using experimental rats and thus to obtain useful data that might be the base for laboratory diagnostics and appropriate therapy of drug abuse and/or intoxications. These studies have been focused on 2C-B (4-bromo-2,5-dimethoxyphenylethylamine) and PMMA (4-methoxymethamphetamine). (...) Drug concentration levels in blood serum or plasma have been low in relation to much higher tissue concentrations which exceeded multiple times blood concentrations. Proven accumulation abilities of both drugs in lungs and delayed but efficient incorporation with persistence in brain tissue are important pharmacokinetic properties that may explain the delayed onsets and prolonged psychotropic potential. PMMA forms the active psychotropic metabolite PMA that has been, in significant concentrations, present in the brain and together...
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