|
|
Vliv náboženství a dalších faktorů na kvalitu partnerských vztahů: porovnání zemí V4
Remešová, Hana
This diploma thesis is focused on the influence of religion on partnerships in the Visegrad Four countries. From the findings of the literature search in the first part of the work, religion becomes an important element in helping the stability of the relationship and individuals tend to find a similar partner. The result of the questionnaire survey was a strong positive relationship, according to which the strength of the long-term partner's faith is also important for believers, which is common to all countries, even if they have a different population structure. In addition, other important features for long-term relationships have been identified, such as kindness and attractiveness.
|
|
|
Mechanisms of phenotypic plasticity induced by genotoxic stress
Přibyl, Miroslav ; Hodný, Zdeněk (advisor) ; Remešová, Hana (referee) ; Vomastek, Tomáš (referee)
Therapy resistance of malignant cells represents the main reason responsible for the failure of cancer therapy. The growth of malignant cells at primary tumour sites but most importantly the dissemination of tumour cells and their growth at secondary sites, are the main reasons why patients eventually succumb to the disease. Even novel immune-based therapies find their limitation in most tumour types. The therapy resistance is mediated by the tumour cells but also by other cellular components of the tumour microenvironment. Understanding the tumour cells mechanisms and the tumour microenvironment features responsible for therapy resistance enables the development of novel therapeutic strategies. Here, we show that ionizing irradiation, 5-azacytidine, and IFNγ treatments induced expression of suprabasin (SBSN) and therapy-resistant low-adherent phenotype in cancer cells. Knockdown of SBSN resulted in suppression of the phenotype. Next, we identified aberrantly elevated SBSN in the bone marrow of a subgroup of myelodysplastic syndromes (MDS) patients. SBSN was expressed by myeloid-derived suppressor cells (MDSCs) and showed significant anti-correlation with T cell abundance and CCL2 levels, hence promises a prognostic value in clinical use. We compiled the most of the relevant knowledge of SBSN...
|
|
|
Mechanisms of phenotypic plasticity induced by genotoxic stress
Přibyl, Miroslav ; Hodný, Zdeněk (advisor) ; Remešová, Hana (referee) ; Vomastek, Tomáš (referee)
Therapy resistance of malignant cells represents the main reason responsible for the failure of cancer therapy. The growth of malignant cells at primary tumour sites but most importantly the dissemination of tumour cells and their growth at secondary sites, are the main reasons why patients eventually succumb to the disease. Even novel immune-based therapies find their limitation in most tumour types. The therapy resistance is mediated by the tumour cells but also by other cellular components of the tumour microenvironment. Understanding the tumour cells mechanisms and the tumour microenvironment features responsible for therapy resistance enables the development of novel therapeutic strategies. Here, we show that ionizing irradiation, 5-azacytidine, and IFNγ treatments induced expression of suprabasin (SBSN) and therapy-resistant low-adherent phenotype in cancer cells. Knockdown of SBSN resulted in suppression of the phenotype. Next, we identified aberrantly elevated SBSN in the bone marrow of a subgroup of myelodysplastic syndromes (MDS) patients. SBSN was expressed by myeloid-derived suppressor cells (MDSCs) and showed significant anti-correlation with T cell abundance and CCL2 levels, hence promises a prognostic value in clinical use. We compiled the most of the relevant knowledge of SBSN...
|
|
|
Vliv impregnace dřeva hovězí krví na jeho odolnost proti dřevokazným houbám
Remešová, Hana
The wood in buildings used to be treated with cattle blood. This paper deals with efficiency of such wood treatment against wood-decaying fungi. The main goal of the theoretical part was to summarize and settle obtainable information about cattle-blood wood impregnation. There were three different recipes based on cattle blood practically tested against brown-rot fungi (Poria placenta) and white-rot fungi (Trametes versicolor). The wood protection against wood-decaying fungi was evaluated as ineffective according to the ČSN EN 839 standard. The reason for wood treatment with blood and possible use in presence are still to be found.
|
guest ::
