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Plasticity in Tablets from Microcrystalline Cellulose
Reich, Filip ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
A study of parameters (power, speed), affect on force - displacement profile, microcrystalline celulose (AVICEL PH - 102® ) and other types of excipients in direct compression 2007, s. 1 - 73 Filip Reich Charles univerzity in Prague, Fakulty of Pharmacy, Institute of Pharmaceutical technology, Heyrovského street 1203, 500 05, Hradec Králové accepted 15th. may 2007 Abstract Compression behaviour, plasticity, of a direct compression excipient, microcrystalline celulose (AVICEL PH - 102), was studied in this work. The compaction property, plasticity, has been acquired with three methods,two procession with the "one-point" plotting, the last one with the "area" plotting. In this work avicel was tableting with slower and more even increase of the compacting power. Yielded results were compared with results from the studies of other laborers, who were solving the same problem by using different compaciton properties, including the speed of tableting 2 mm/s, and using also the same excipients. The acquired plasticity indicated, that these methods gave compareable results. In the force - plasticity profile we can find two apparent slots, the first characterize the phase before the start of compaction, the second one shows the phase of plastic deformation. The character of the force - plasticity curve in the phase...
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Plasticity in Tablets from Microcrystalline Cellulose
Reich, Filip ; Řehula, Milan (advisor) ; Musilová, Marie (referee)
A study of parameters (power, speed), affect on force - displacement profile, microcrystalline celulose (AVICEL PH - 102® ) and other types of excipients in direct compression 2007, s. 1 - 73 Filip Reich Charles univerzity in Prague, Fakulty of Pharmacy, Institute of Pharmaceutical technology, Heyrovského street 1203, 500 05, Hradec Králové accepted 15th. may 2007 Abstract Compression behaviour, plasticity, of a direct compression excipient, microcrystalline celulose (AVICEL PH - 102), was studied in this work. The compaction property, plasticity, has been acquired with three methods,two procession with the "one-point" plotting, the last one with the "area" plotting. In this work avicel was tableting with slower and more even increase of the compacting power. Yielded results were compared with results from the studies of other laborers, who were solving the same problem by using different compaciton properties, including the speed of tableting 2 mm/s, and using also the same excipients. The acquired plasticity indicated, that these methods gave compareable results. In the force - plasticity profile we can find two apparent slots, the first characterize the phase before the start of compaction, the second one shows the phase of plastic deformation. The character of the force - plasticity curve in the phase...
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Calculation of elasticity and plasticity of microcrystalline cellulose Avicel PH 103
Reich, Filip ; Řehula, Milan (advisor) ; Špaček, Vladimír (referee)
Calculation of Elasticity and Plasticity of Microcrystalline Cellulose Avicel® PH - 103 Mgr. Filip Reich, Hradec Králové 2008 Avicel® PH - 103, well-known type of microcrystalline cellulose, is an important pharmaceutical excipient. Solid technological forms use to contain Avicel for its ability to reduce addition amount of pharmaceutical powders, tablets especially. Avicel also facilitates tableting of pressing power, this fact is important for therapeutical agents, that are sensitive for high pressure. The aim of this work was the definition and calculation of elasticity and plasticity of microcrystalline cellulose Avicel® PH - 103. The plasticity was determined from the "force - time" profile with three different methods. The first one was based on the proportion of the highest and the lowest pressing force. The second one used "one - parameter" evaluation of the "force - time" profile and the last one was established by using "three - parameter" rate. Further we had to determine Young's modulus, the elasticity character of system. The value equals 100,75023 MPa. From the "plasticity - force" profile we were able to distinguish the all compression phases with eventual progressing changes. Exactly there was the phase of precompression followed by the elastic and then the plastic deformation. This...
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