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Dopad alimentární expozice bisfenolu S na vybrané orgány laboratorních potkanů
ROČEŇOVÁ, Adéla
The present thesis investigated the impact of a ten-week oral exposure to BPS (50 ?g/kg live weight/day) in female outbred Wistar Han rats. The effect of BPS exposure on live weight, absolute and relative kidney and liver weights, morphometric parameters of kidney and renal corpuscles, histopathological changes of kidney and liver were evaluated. In addition, the concentration of total protein, triacylglycerols, cholesterol, urea and alanine aminotransferase activity were determined in blood serum.
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Postnatální změny ledvin králíka
ROČEŇOVÁ, Adéla
The kidneys are the main excretory organ that completes morphological and functional development in a species-different postnatal period of an individual's life. This bachelor thesis dealt with morphometric and histological changes in the kidneys of rabbits. The study included 42 New Zealand white rabbits at the age of 0, 5, 10, 14, 19, 27, 32 days. During this period, the length, width and weight of the kidneys and histological changes were determined, and at the age of 14, 19, 27, 32 days also the length, width, area and number of renal corpusles. In newborn rabbits, the average kidneys length was 9.75+-0.66 mm and the width was 5.88+-0.78 mm. Over 32 days, length increased by 117.44% (21.2+-1.71 mm) and width by 144.90 % (14.4+-1.61 mm). The most significant increase in kidneys length and width occurred in the first 19 days of life (length 110.26 %, width 144.56 %). The average kidneys weight of the newborn rabbit was 0.25+-0.03 g and 2.40+-0.83 g on day 32. A nephrogenic zone and nephrons type I and II were observed in the kidneys up to 10 days of age. By day 19, nephrons type III were present. The onset of marrow differentiation into inner and outer zones was noted at 10 days and at 14 days the zones were fully distinguishable. In 14-day-old individuals, the average length of renal corpusles was 55.10+-6.32 um, width 67.51+-8.91 um and area 3125.25+-778.99 um2. In 32 days, the length reached 76.90+-6.26 um, the width 93.96+-6.10 um and the area 5963.06+-851.05 um2. High correlation coefficients ranging from 0.886 to 0.972 were found between body weight and renal morphometric parameters. High correlation coefficients were found also between the weight of the kidneys and the morphometric parameters of the renal corpuscles. A negative coefficient was found between the area and the number of renal corpuscles (rxy = -0.997).
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