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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period
 REZKOVÁ, Markéta
Tumour necrosis factor (TNF) is one of the most important pro-inflammatory cytokines of the innate immune system. We compared the presence of anti-TNF activity in saliva or salivary gland extract from 11 tick species from the family Ixodidae and demonstrated it in genera Ixodes and Haemaphysalis. We also tested dynamics of this specific activity in Ixodes ricinus saliva. The highest effect of saliva appears at the end of feeding period. Significance of anti-TNF activity for tick feeding and transmission of tick-borne pathogens is discussed.
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Pokus o charakterizaci proteinu vázajícího TNF - \recke{alpha} ve slinách klíštěte \kur{Ixodes ricinus}
 REZKOVÁ, Markéta
Tumor necrosis factor is one of the most important pro-inflammatory cytokines of the innate immune system. We tested several species of ticks for anti-tumour necrosis factor- activity in this study. The specific activity was proved for Ixodes ricinus saliva and several other species. We also tested dynamics of this specific activity in Ixodes ricinus saliva. The highest effect of saliva appears at the end of feeding period. Although we detected an inhibitory effect, none TNF-binding molecule has been identified so far. Our results excluded enzymatic aktivity cleaving TNF molecule.
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The syndrome of familial atypical multiple mole melanoma (FAMMM): the importance of preventive genetic testing by mutation analysis of the genes CDKN2A and CDK4
 REZKOVÁ, Markéta
In the theoretical part malignant melanoma are being characterized in terms of the visual aspect, the origin, the increasing incidence and the treatment. A special attention is turned to the importance of CDKN2A gene and CDK4 gene in cell proliferation of melanocytes and to the molecular interactions associated with the process. Furthermore, I present frequently described mutations of CDKN2A gene and CDK4 gene in familiarly formed melanoma, the importance of prevention and genetic testing. The practical part deals with the methodology that I used for mutational analysis of genes CDKN2A and CDK4.
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See also: similar author names
2 Rezková, Michaela
72 Rezková, Miluše
2 Rezková, Monika
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