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Image guided radiotherapy - IGRT
RÁKOSNÍKOVÁ, Štěpánka
This bachelor thesis deals with the general description of modern irradiation techniques and the verification technique IGRT The picture of the controlled radiation therapy, which was put into operation in the hospital České Budějovice a.s. in the year 2015. It deals with two ways of verification used during irradiation of the prostate in the hospital with 2D Mv-kV and CBCT pictures. Radiation therapy is a young and rapidly growing field in medicine. Presently, there has been a big change in instrumentation used in radiotherapeutic divisions. Today on most of the Czech Republic work places it is a standard to have the option to use IMRT techniques (radiation therapy with modulated intensity). This technique, thanks to intensity modulation across the beam of radiation and dose distribution corresponding with the target volume allows maximal saving of the healthy surrounding tissue. With the use of IMRT technology, which enables to increase doses applied to the volume goal, the requirement for the verification system increased. That is why radiation therapy controlled by pictures IGRT is slowly being introduced, it ensures higher accuracy in the setting of the position of the patient. This verification method shifts present methods irradiation to a higher level and especially in safety and the quality of the execution of the irradiation. This works goal is to obtain information about verification methods used in the hospital České Budějovice a.s., which are verifications through 2D pictures Mv-kV and CBCT (cone beam CT). Further the subject of the research is the observation of corrections of imbalances that are, used after these two verification methods are utilized, related only for diagnosing prostate cancer. This diagnosis was chosen because it belongs to the most occurring cancer of the male population, which has an increased incidence. Another reason for focusing on this cancer are the requirements for accuracy on locating the volume goal which is in the vicinity if a lot of critical structures. Answer to the investigative question "how big are the corrections of imbalances used after the verification of MV-kV pictures and CBCT" was made based on the analysis of the assembled corrections of 54 patients, who were treated in the hospital of České Budějovice with the diagnosis of prostate cancer within the last two years. In the conclusion of this work there are calculations of made verifications based on MV-kV and CBCT pictures in a summarized table. The pictures were recorded only if both methods were used in one day in a fractional regime. The reason was evaluating potential differences of the used corrections based on 2D pictures and CBCT. Next, in the table, there are calculations of significant deviation over 3mm during CBCT verifications and previous verifications according to 2D pictures MV-kV. All these recorded deviations are commented and explained. The goal of this paper is proof of the importance of more accurate verification methods whilst using IMRT irradiation technique. This paper points out on unaffected movements of the inner organs, which are near the irradiated volume, and on the importance of the preparation of the patient before the irradiation and affected focus of the volume goal with an uncooperative patient. The content of this bachelor thesis can provide basic view about current irradiation and verification techniques to students of medical fields. This Information can be used as a subject matter for processing research and professional articles that focus on a similar topic.

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