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Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method
Pospíchalová, Jana ; Vejsová, Marcela (advisor) ; Fikrová, Petra (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Jana Pospíchalová Supervisor: Mgr. Marcela Vejsová, Ph.D. Title of diploma thesis: Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method The aim of this thesis is to evaluate activity of potentional antibacterial substances synthesized at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové. For testing of the antimicrobial activity was used microdilution broth method. This method is suitable for the quantitative determination of antimicrobial susceptibility. The substances were tested at eight bacterial strains, which consisted of Gram pozitive and Gram negative bacteria including resistant agents of serious nosocomial infections. 52 tested substances were dividend into 6 groups based on a common structure. The most effective group was evaluated by a group of N-benzyl-3-chloro-pyrazin-2-carboxamide and the most effective substance of all tested was 3-chloro-N- (3,4-dichlorobenzyl) pyrazine-2- carboxamide belonging to this group. Most sensitive to the tested substances showed Staphylococcus aureus and Staphylococcus epidermidis.
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Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method
Pospíchalová, Jana ; Vejsová, Marcela (advisor) ; Fikrová, Petra (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Jana Pospíchalová Supervisor: Mgr. Marcela Vejsová, Ph.D. Title of diploma thesis: Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method The aim of this thesis is to evaluate activity of potentional antibacterial substances synthesized at the Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové. For testing of the antimicrobial activity was used microdilution broth method. This method is suitable for the quantitative determination of antimicrobial susceptibility. The substances were tested at eight bacterial strains, which consisted of Gram pozitive and Gram negative bacteria including resistant agents of serious nosocomial infections. 52 tested substances were dividend into 6 groups based on a common structure. The most effective group was evaluated by a group of N-benzyl-3-chloro-pyrazin-2-carboxamide and the most effective substance of all tested was 3-chloro-N- (3,4-dichlorobenzyl) pyrazine-2- carboxamide belonging to this group. Most sensitive to the tested substances showed Staphylococcus aureus and Staphylococcus epidermidis.
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Grants in the accounting and taxes
Pospíchalová, Jana ; Müllerová, Libuše (advisor) ; Zelenková, Marie (referee)
Thesis on the topic of Grants in the accounting and taxes is aimed maily at displaying of grants in accounting for entrepreneurs. This work at first analyzes different kinds and forms of grants and its sources, displaying in accounting and taxes and there is also a description of an international approach according to International Financial Reporting Standards. There is also a chapter about National Accounting Board and its Interpretations in particular those relating to grants. Each chapter is supplemented by practical examples that show different ways of capturing grants.
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