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National Repository of Grey Literature

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Prognostic and Predictive Factors in Patients with Metastatic Colorectal Cancer Treated with Targeted Therapy Šorejs, Ondřej ; Fiala, Ondřej (advisor) ; Pešta, Martin (referee) ; Poprach, Alexandr (referee) Introduction: In recent years, significant progress has been made in the treatment of metastatic colorectal cancer (mCRC) due to the use of targeted therapy. Bevacizumab is a monoclonal antibody (mAb) against vascular endothelial growth factor (VEGF) and cetuximab and panitumumab are monoclonal antibodies against epidermal growth factor receptor (EGFR). MicroRNAs (miRs) are single-stranded non-coding RNA chains of 18-25 nucleotides in length that are involved in the regulation of gene expression and thus significantly influence the biological behaviour of cancer cells. Dysregulations at the miR level are considered promising candidates for prognostic and predictive biomarkers. Aims: The aim of this work, divided into two parts, was to evaluate the association of dysregulation of selected miRs with the effect of targeted therapy in patients with mCRC. Methods: The first study included 63 mCRC patients treated with chemotherapy and bevacizumab. The second study included 46 mCRC patients treated with chemotherapy and cetuximab or panitumumab. Assessment of treatment effect included progression-free survival (PFS), overall survival (OS), objective response rate (ORR) and disease control rate (DCR). Samples of frozen tumor and adjacent non- tumor tissue obtained during primary tumor surgery were used... Detailed record

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