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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Skryté klustery genů sekundárního metabolizmu u Streptomyces ambofaciens
 Nezbedová, Šárka ; Karray, F. ; Juguet, M. ; Aigle, B. ; Pernodet, J. L. ; Weiser, Jaroslav
We looked for conditions leading to activation of silent gene clusters implied from the sequence as responsible for biosynthesis of yet unknown secondary metabolites in mutants blocked in biosynthesis of known antibiotics (spiramycin, congocidin). This approach should contribute to the better understanding of interaction between primary and secondary metabolism during production of antibiotics and the role of morphological differentiation in these processes
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Intrinsic macrolide resistance in Mycobacterium tuberculosis compex
 Buriánková, Karolína ; Doucet-Populaire, F. ; Weiser, Jaroslav ; Dorson, O. ; Gondran, A. ; Ghassia, J. C. ; Pernodet, J. L.
The intricsic resistance of Mycobacteria to most common antibiotics and chemotherapeutic agents is generally attributed to the low pemeobility of their complex cell wall.
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