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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Prevention of postinfarction left ventricular remodeling with stem cells implantation
 Pelnař, Jiří ; Moťovská, Zuzana (advisor)
Cell therapy is a tempting and possibly promising therapeutic approach, which could be used in the near future to prevent the serious health effects on the heart and thus on the whole human organism resulting from myocardial infarction. The portion of the heart afflicted by infarction disrupts the architecture of the heart chamber as a whole and causes it to undergo the process of remodeling in a less or more pronounced manner. This process leads to progressive deterioration of the heart function, which may eventually lead to heart failure. The potential regeneration of a viable heart tissue by stem cells implantation would have the means of ceasing or reverting this harmful process. The introduction of stem cells into the heart tissue following a myocardial infarction can be achieved by several different techniques, using various cell types and in various time intervals after the occurence of myocardial infarction. So far, a number of studies using animal models of myocardial infarction, have shown that the stem cells implantation has a favorable effect on the restoration of heart function, while not showing such occurence of adverse effects that would exclude further investigation in the form of clinical studies. The clinical studies described in this work do not allow to make a definite conclusion. Some...
Detailed record
Prevention of postinfarction left ventricular remodeling with stem cells implantation
 Pelnař, Jiří ; Moťovská, Zuzana (advisor)
Cell therapy is a tempting and possibly promising therapeutic approach, which could be used in the near future to prevent the serious health effects on the heart and thus on the whole human organism resulting from myocardial infarction. The portion of the heart afflicted by infarction disrupts the architecture of the heart chamber as a whole and causes it to undergo the process of remodeling in a less or more pronounced manner. This process leads to progressive deterioration of the heart function, which may eventually lead to heart failure. The potential regeneration of a viable heart tissue by stem cells implantation would have the means of ceasing or reverting this harmful process. The introduction of stem cells into the heart tissue following a myocardial infarction can be achieved by several different techniques, using various cell types and in various time intervals after the occurence of myocardial infarction. So far, a number of studies using animal models of myocardial infarction, have shown that the stem cells implantation has a favorable effect on the restoration of heart function, while not showing such occurence of adverse effects that would exclude further investigation in the form of clinical studies. The clinical studies described in this work do not allow to make a definite conclusion. Some...
Detailed record

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