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Synthesis and study of O- and N-modified ceramides
Pavlíková, Ludmila ; Vávrová, Kateřina (advisor) ; Roh, Jaroslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Ludmila Pavlíková Supervisor: doc. PharmDr. Kateřina Vávrová, Ph.D. Title of diploma thesis: Synthesis and study of O- and N-modified ceramides Ceramides which are composed of fatty acid and basic alcohol, naturally occur in the human body and play a role in many physiological processes. They are known like molecules participating in the cell signaling, they take part in differentiation, proliferation and apoptosis of the cell but they are also structural elements of cell membrane. Last but not least, they are included in extracellular matrix of stratum corneum where they participate in the barrier function of the skin. In addition to research of naturally occurring ceramides, of course it is necessary to study various modifications of these substances and to find connections between structure of ceramides and their ability to keep the barrier function. 1-deoxy, 3-deoxy a N-methyl analogues of ceramides, that I investigate in my diploma thesis, have not been examined yet in terms of their barrier function. Before the measuring of the properties of model membranes consisting of these analogues, it was necessary to synthesize these analogues. Synthesis was performed in two ways....
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