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Proteomics, Lymphocyte Population in Multiple Sclerosis and Disability
Pavelek, Zbyšek ; Vališ, Martin (advisor) ; Mareš, Jan (referee) ; Hradílek, Pavel (referee)
Introduction Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease affecting the central nervous system. Although research on the diagnosis and treatment of this serious illness has made significant advances, the MS etiology remains unknown. Although there is still much to be found in the MS pathogenetic mechanisms, understanding the mechanisms of immune-mediated damage to the central nervous system (CNS) components of MS allows not only the introduction of new drugs that positively modulate inflammatory inflammation but also the understanding of immune- mediated diseases affecting the CNS in a broader sense. Methods The Ph.D. thesis is a general introduction followed by an annotated set of author's publications on proteomics, lymphocytic population in MS and disability. Study 1: Proteomic analysis of cerebrospinal fluid for relapsing-remitting multiple sclerosis and clinically isolated syndrome was conducted to find changes in the low molecular cerebrospinal fluid (CSF) segment and to determine what native peptides and how much they are in cerebrospinal fluid among patients with clinically isolated syndrome (CIS) and relapsing-MS (RR MS) compared to a healthy population. Study 2: Lymphocytes in the treatment with interferon beta-1b targeted individual...
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Selected aspects from monitoring mine rescuers´ exposure to heat
Pavelek, Zdeněk
The responses of mine rescuers in worsened microclimatic conditions are among the most arduous and risky operations undertaken by mine rescue crews. The standard method of monitoring mine rescuers´ exposure to heat consists of manually measuring the temperature (relative humidity) of the mine atmosphere both en route and on site and further, of monitoring the actual physical condition of mine rescuers by measuring their pulse rate. From the measurement of the temperature (relative humidity) in the mine atmosphere, the duration of responses without wearing breathing apparatuses, or when wearing them, can subsequently be determined by means of tabulated values. New trends in monitoring the mine rescuers´ exposure to heat mainly accentuate continuous evaluation of the current physical condition of every individual mine rescuer in action, while this evaluation is based on continuous measurement of the physiological quantities of physical organism. This method of monitoring mine rescuers´ exposure to heat represents a significant improvement in safety when guiding responses of mine rescue services during mining activity in underground mines.
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