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Synthesis of amides of 3,4-benzotropolone-carboxylic acid
Panýrková, Gabriela ; Machara, Aleš (advisor) ; Rýček, Lukáš (referee)
Tropolone and benzotropolone are both naturally occurring motifes with broad spectrum of bioactivities and interesting properities that are connected to these structures. This bachelor thesis explores preparation of 3,4,6-trihydroxy-5H-benzo[7]annulen-5-one, so called purpurogallin and it's possible preparation by enzyme catalyzed reactions and further synthetic use of these products. The study is mainly focused on synthesis of 3,4-benzotropolon- carboxylic acid, specially it's amides. First part deals with choosing the optimal reaction conditions for formation of these amides. In the next part palladium catalyzed carboxylations were performed on prepared bromoderivate of dehydroxypurpurogallin. Key words tropolones, benzotropolones, dehydroxypurpurogallin-4-carboxylic acid, amides, optimization, enzymatic catalysis, carboxylation
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The role of teaching assistant in promoting inclusive education of children with autism spectrum disorders and mental disabilities in selected kindergarten
Panýrková, Gabriela ; Marádová, Eva (advisor) ; Němec, Zbyněk (referee)
This bachelor thesis deals with the role of a teaching assistant in promoting inclusive education of children with autistic spectrum disorders, and mental disabilities in pre-primary education. The main goal of it, is to find out and describe the experiences that teachers and teaching assistants have in a selected kindergarten, with the joint education of children that are on the autistic spectrum or the ones with mental disabilities. An equally important part of the work are the opinions the teachers have on the benefits of the subject. The theoretical part describes mental disability, autistic spectrum disorders and the role of a teacher assistant in Czech education. It describes specifics of educating children with autistic spectrum disorders and mental disability in common kindergarten. Besides that, the thesis deals with the inclusive education in its current form, both in Czech educational system and on the global scale. Practical part is focused on figuring out the approach to the role of teacher's assistant from the point of view of the pedagogical staff of the selected kindergarten. A qualitative type of research was chosen for the data collection, in which the technique of semi-structured interview with individual participants of the research was used. The analyzed data proves that in the...
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