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Pyrazine derivatives as a potential drugs
 Molnárová, Marie ; Doležal, Martin (advisor) ; Zitko, Jan (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical analysis Student: Mgr. Marie Molnárová Supervisor: Prof. PharmDr. Martin Doležal, Ph.D. Co-advisor: PharmDr. Ondřej Janďourek, Ph.D. Title of rigorous work: Pyrazine derivatives as a potential drugs Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis is a global problem because it is the most common cause of death among infectious diseases. The complication of therapy is the rise of multiresistant and extremely resistant strains. The synthesis of novel substances is focused to gain safer and active drugs. This work is focused on the synthesis of pyrazine derivatives in which substitution of pyrazine cycle with various substituents is used. It follows up the research which is established at the Department of Pharmaceutical Chemistry, Pharmaceutical Faculty in Hradec Králové. The pyrazinamide is the first line antituberculotic drug. The previous studies proved that substitution of pyrazine ring with various substituents can increase the antituberculotic and/or antifungal activity. In this work it is used aminodehalogenation reaction, the 2-chloropyrazine, as a starting substance, reacts with ring-substitued benzylamine in microwave reactor. In this...
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See also: similar author names
2 Molnárová, Marika
2 Molnárová, Martina
8 Molnárová, Monika
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