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The Study Efficiency of Utilization of Workplacess in Selected Operation
Milota, Tomáš ; Tesař, Rostislav (referee) ; Jurová, Marie (advisor)
This thesis deals with the analysis of data obtained by observing and measuring workplaces of assembly lines with a focus on the efficiency of their utilization, through selected elements of industrial engineering, which the reader can get acquainted with in the theoretical part of the thesis. In this thesis the line productivity during the shifts is analyzed, an ideal line balancing condition is defined and suggestion for changing the time of line consumption norm according to the measured line cycle time is made. According to the complex analyzes of the workplaces, suggestions are concluded and an economic appreciation of these proposals is also elaborated. The author of this thesis finds the main benefit of this work in increasing of the productivity of the analyzed line in the case of implementation of solution designs.
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Dysregulation of immune system in the patients with Common Variable Immunodeficiency
Milota, Tomáš ; Horváth, Rudolf (advisor) ; Stříž, Ilja (referee) ; Freiberger, Tomáš (referee)
This thesis includes set of published experimental results, which were obtained at the Department of Immunology, Second Faculty of Medicine Charles University within the project focused on the basal and applied research of the Primary immunedeficiencies (PID), particularly Common variable immunodeficiency (CVID). The first, theoretical part, is divided into two sections. The first section is dedicated to the general aspects of Primary antibody deficiencies (PAD). The second section is focused on epidemiology, ethiopathogenesis, classification, clinical and therapeutical aspects of CVID. The main consideration is devoted particularly to non-infectious complications, which significantly contribute to morbidity and mortality of CVID patients. The second part consists of the set of publications describing specific mechanisms of immune system dysregulation and their clinical manifestation, which are briefly commented. The spectrum of issues resolved within the project covers following basic aspects: 1) characteristics of lung complications in CVID from the point of view of bronchial asthma, 2) characteristics of associated malignancies, 3) significance of genetic background for the specific treatment, 4) therapy of CVID focused on aspects of immunoglobulin substitution. The results of the other...
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The Study Efficiency of Utilization of Workplacess in Selected Operation
Milota, Tomáš ; Tesař, Rostislav (referee) ; Jurová, Marie (advisor)
This thesis deals with the analysis of data obtained by observing and measuring workplaces of assembly lines with a focus on the efficiency of their utilization, through selected elements of industrial engineering, which the reader can get acquainted with in the theoretical part of the thesis. In this thesis the line productivity during the shifts is analyzed, an ideal line balancing condition is defined and suggestion for changing the time of line consumption norm according to the measured line cycle time is made. According to the complex analyzes of the workplaces, suggestions are concluded and an economic appreciation of these proposals is also elaborated. The author of this thesis finds the main benefit of this work in increasing of the productivity of the analyzed line in the case of implementation of solution designs.
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