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Use of DSC for Evaluation of Single Medicines I.
Melezínková, Pavla ; Musilová, Marie (advisor) ; Doležal, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Technology Candidate Mgr. Pavla Melezínková Consultant RNDr. Marie Musilová, CSc. Title of Thesis Use of DSC for evaluation of single medicines I. This thesis is part of the thesis, which deals with posibility of setting the contain of active substances in individual medicines using the differential scanning calorimetry. To set up this type, it is necessary the presence of evaluated peak on DSC curved line, which value ΔH is proportional to the amount of incorporated active substance. The theoretical part shows summary about all rectal active substances in the Czech Republic. There is summary of contained active substances at suppositories valued by DSC method and their quantitative presence in each substance. In the experimental part, there are next presented microscopic shots, which prove the presence of suspended active substances in suppositories. There are also notes and evaluation of calorimetry measuring and at the group of preparations, there is compared the declared amount of substance with the value specified with DSC. Key words: DSC, suppositories, active substances
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Measurement of nanoviscosity of polymer solutions using nanoprobes and DLS.
Melezínková, Pavla ; Berka, Pavel (advisor) ; Doležal, Pavel (referee)
Theoretical part of this work briefly reviews nanomaterials, formation of nanoparticles and their utilization in pharmacy. Further, it deals with viscosity and options for its measurement in both macro- and nanoscale and concisely describes properties and applications of hyetellose and hyprollose. Macroviscosity and nanoviscosity of colloid solutions of polymers P1, P2 and P3 in concentrations 0,03125 %, 0,0625 %, 0,125 %, 0,25 % a 0,5 % were determined in experimental part of this work. Polystyrene nanoparticles sized 20 nm, 60 nm and 100 nm were used as nanoprobes. Diffusion coefficients were measured by DLS and used for calculation of nanoviscosity. Determined nanoviscosity was compared with macroviscosity acquired by measurement using Ubbelohde capillary viscometer. It is apparent from the comparison of the obtained values of relative macroviscosity and relative nanoviscosity that movement of nanoparticles of used size in dilute dispersions of polymers P1, P2 and P3 is more substantially affected by nanoviscosity than by macroviscosity. Keywords: DLS, nanoprobes, nanoviscosity, (macro-)viscosity
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Use of DSC for Evaluation of Single Medicines I.
Melezínková, Pavla ; Musilová, Marie (advisor) ; Doležal, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Technology Candidate Mgr. Pavla Melezínková Consultant RNDr. Marie Musilová, CSc. Title of Thesis Use of DSC for evaluation of single medicines I. This thesis is part of the thesis, which deals with posibility of setting the contain of active substances in individual medicines using the differential scanning calorimetry. To set up this type, it is necessary the presence of evaluated peak on DSC curved line, which value ΔH is proportional to the amount of incorporated active substance. The theoretical part shows summary about all rectal active substances in the Czech Republic. There is summary of contained active substances at suppositories valued by DSC method and their quantitative presence in each substance. In the experimental part, there are next presented microscopic shots, which prove the presence of suspended active substances in suppositories. There are also notes and evaluation of calorimetry measuring and at the group of preparations, there is compared the declared amount of substance with the value specified with DSC. Key words: DSC, suppositories, active substances
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Measurement of nanoviscosity of polymer solutions using nanoprobes and DLS.
Melezínková, Pavla ; Berka, Pavel (advisor) ; Doležal, Pavel (referee)
Theoretical part of this work briefly reviews nanomaterials, formation of nanoparticles and their utilization in pharmacy. Further, it deals with viscosity and options for its measurement in both macro- and nanoscale and concisely describes properties and applications of hyetellose and hyprollose. Macroviscosity and nanoviscosity of colloid solutions of polymers P1, P2 and P3 in concentrations 0,03125 %, 0,0625 %, 0,125 %, 0,25 % a 0,5 % were determined in experimental part of this work. Polystyrene nanoparticles sized 20 nm, 60 nm and 100 nm were used as nanoprobes. Diffusion coefficients were measured by DLS and used for calculation of nanoviscosity. Determined nanoviscosity was compared with macroviscosity acquired by measurement using Ubbelohde capillary viscometer. It is apparent from the comparison of the obtained values of relative macroviscosity and relative nanoviscosity that movement of nanoparticles of used size in dilute dispersions of polymers P1, P2 and P3 is more substantially affected by nanoviscosity than by macroviscosity. Keywords: DLS, nanoprobes, nanoviscosity, (macro-)viscosity
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