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The Significance of Ultrasound Examination in the Management of Experimental Uterine transplantation
Matěcha, Jan ; Chmel, Roman (advisor) ; Zikán, Michal (referee) ; Roztočil, Aleš (referee)
The significance of ultrasound examination in the management of experimental uterine transplantation Abstract Uterine transplantation (UTx) represents a new experimental method of treatment of absolute uterine factor infertility (AUFI), which includes inability to conceive and deliver as a result of absence of the uterus. This can be congenital (Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS)) or acquired (after hysterectomy, severe congenital uterine malformations). For a woman affected this way is the uterine transplantation the only way to give birth to a child by herself. This is a very sophisticated and invasive procedure for the treatment of sterility with promising results, but the woman - recipient of the uterus - is burdened by at least three abdominal surgeries (transplantation, Caesarean section, explantation), in vitro fertilization and by the need to use immunosuppressive therapy. The dissertation summarizes current knowledge on this issue from the perspective of a gynecologist-obstetrician, who regularly examined by ultrasound or gynecologically participants in the Czech uterine transplant study in 2016-2019, which was carried out on the basis of a cooperation agreement between two Prague hospitals - IKEM and FN Motol. The set contains data on ten patients with a transplanted uterus, five from...
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