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Clay minerals as drug stabilizers
Markytánová, Petra ; Rabišková, Miloslava (advisor) ; Vraníková, Barbora (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Farmaceutické technologie Consultant: prof. PharmDr. Miloslava Rabišková, CSc. Student: Petra Markytánová Title of Thesis: Clay minerals as drug stabilizers This thesis presents clay minerals as drug stabilizers. The aim of thesis was introduction of phyllosilicates, kaolinite, talc, smectites and fibrous clays which belong to the most important minerals. These clays are widely used as active substances or excipients in the formulation of dosage forms such as solid, liquid or semisolid. The structure, classification and useful properties directly related to their colloidal size and structure are shortly disscussed. Clay minerals posses excellent properties such as high adsorption capacity, swellability, low or null toxicity, good biokompatibility and promise for controlled release, thus give rise to the incess and interest to their development for biological purposes. The important chapter are current challenges in pharmaceutical applications. Besides classic pharmaceutical uses, clay minerals may be effectively used in formulations for controlled drug delivery systems. A very interesting possibility is to use clay minerals polymer composites, that can be used to prepare the nanoparticles, films, hydrogels or...
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