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Automated monitoring of sulisobenzone liberation through model membrane
 Marel, David ; Sklenářová, Hana (advisor) ; Chocholouš, Petr (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of analytical chemistry Candidate: David Marel Supervisor: assoc. prof. PharmDr. Hana Sklenářová, Ph.D. Title of the diploma thesis: Automated monitoring of sulisobenzone liberation through model membrane This diploma thesis deals with the monitoring of biologically active substance liberation through a model membrane using sequential injection analysis. A UV - VIS spectrophotometer was used for the detection. The tested biologically active substance was sulisobenzone (one of the UV filters used in sunscreens) and the permeation through the polycarbonate membrane was monitored using a Franz cell. At the beginning of the work, a calibration curve was created in two media - water and phosphate buffer of pH 7.4. According to these curves, the concentrations - which were further used in the liberation tests - were selected. The given concentrations of sulisobenzone were prepared in different solvents, namely in water, in 10% ethanol, in 10% propylene glycol and in 5% propylene glycol. The tested solvents were selected based on the assumption of increasing the permeability of the membrane for the liberation of substances with limited solubility in the liberation medium. Each tested solution was measured for 2 hours, with individual...
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